Stent having active release reservoirs

• US 20060217798A1
• Filed: 03/10/2006
• Published: 09/28/2006
• Est. Priority Date: 11/17/1999
• Status: Abandoned Application

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Inventors: Santini, John T. Jr., Hutchinson, Charles E.
• Application Number:
  US11/373,805
• Publication Number:
  US 20060217798A1
• Time in Patent Office: Days
• US Class Current: 623/1.420
• CPC Class Codes: A23L 2/52 Adding ingredients adding preservatives A23L2/44
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2250/0035 differing in release or diffusion time
• CPC Class Codes: A61F 2250/0068 the pharmaceutical product being in a reservoir
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61L 2300/416 Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 15/0031 by bursting or breaking the package, i.e. without cutting or piercing
• CPC Class Codes: A61M 15/0045 using multiple prepacked dosages on a same carrier, e.g. blisters
• CPC Class Codes: A61M 15/005 the dosages being arranged on a cylindrical surface
• CPC Class Codes: A61M 15/008 Electronic counters
• CPC Class Codes: A61M 15/0083 Timers
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 2205/8225 using incorporated gas cartridges for the driving gas
• CPC Class Codes: A61M 5/1407 Infusion of two or more substances

Abstract

Devices for the controlled release of one or more drugs are provided. The devices include an implantable stent, at least two reservoirs in the stent, and a release system contained in each of the at least two reservoirs, wherein the release system comprises one or more drugs for release.

Claims

1. An implantable stent for delivering a substance comprising:

a first reservoir defining a first opening, and containing a first substance therein;

a first anode overlying at least a portion of the first opening; and

a first cathodes located proximate the first anode;

wherein the first cathode and the first anode are configured to permit application of an electric potential therebetween.

2. The stent of claim 1, wherein the first substance is a drug.

3. The stent of claim 1, wherein the first cathodes comprises two portions located proximate opposite sides of the first anode.

4. The stent of claim 1, wherein the first anode is comprised of a film-like conductive material.

5. The stent of claim 1, wherein the first anode is comprised of a material capable of dissolving upon application of the electric potential.

6. The stent of claim 1, wherein the first anode is comprised of a material capable of forming soluble ions or oxidation compounds upon application of an electric potential.

7. The stent of claim 5, wherein the first substance is at least partially released upon dissolution of at least a portion of the first anode.

8. The stent of claim 1, wherein the first anode completely covers the first opening.

9. The stent of claim 1, wherein the first anode is a reservoir cap.

10. The stent of claim 1, further comprising a second reservoir having a second opening, and containing a second substance therein.

11. The stent of claim 10, wherein the second reservoir is located adjacent the first reservoir.

12. The stent of claim 10, wherein the second reservoir is located substantially beneath the first reservoir.

13. The stent of claim 1, wherein the stent is configured to actively release the first substance.

14. The stent of claim 1, wherein the stent is configured to release the first substance within a living being.

15. An implantable stent for delivering a substance comprising:

a first reservoir defining a first opening, and containing a first substance therein; and

a first cap overlying at least a portion of the first opening;

wherein the first cap is configured to be at least partially dissolved in response to an electric potential, thereby releasing at least a portion of the first substance.

16. The stent of claim 15, wherein the stent is configured to release the first substance within a living being.

17. The stent of claim 15, wherein the first cap is an anode.

18. The stent of claim 17, further comprising at least one cathode.

19. The stent of claim 15, further comprising:

a second reservoir having a second opening, containing a second substance therein; and

a second cap overlying at least a portion of the second opening;

wherein the second cap is configured to be at least partially dissolved in response to an electric current or potential, thereby releasing at least a portion of the second substance.

20. The stent of claim 19, wherein the second reservoir is located adjacent the first reservoir.