Nasal delivery device
5 Assignments
0 Petitions
Accused Products
Abstract
A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.
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Citations
136 Claims
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1-34. -34. (canceled)
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35. A device for delivering a substance to the nasal airway of a subject, comprising:
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a flow resistor; and
a nosepiece shaped and sized for insertion into a nostril of the subject to create a fluid tight seal with the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject, and the fluid tight seal is maintained at all times while the subject is exhaling and under the full range of operational fluid flow pressures. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A device for delivering a substance to the nasal airway of a subject, comprising:
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a flow resistor; and
a nosepiece shaped and sized for insertion into a nostril of the subject to create a fluid tight seal with the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject, and the device is configured to deliver a substance entrained in a gas flow having a positive pressure in the nasal airway of at least 50 cm H2O. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59)
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60. A device for delivering a substance to the nasal airway of a subject, comprising:
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a flow resistor;
a nosepiece shaped and sized for insertion into a nostril of the subject to create a fluid tight seal with the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject; and
a substance supply unit in fluid communication with the outlet of the nosepiece and configured to entrain a substance in a gas flow at a pressure sufficient to maintain a flow path beyond the posterior margin of the nasal septum of the subject;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject. - View Dependent Claims (61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72)
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73. A device for delivering a substance to the nasal airway of a subject, comprising:
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a first flow resistor;
a delivery unit for delivering a substance in a gas flow to one of the nostrils of the subject at a driving pressure sufficient to cause the gas to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril; and
an outlet unit comprising a nosepiece for fitting in the other nostril and a second flow resistor for providing a flow resistance to the gas flow exiting the other nostril so as in use to maintain a positive pressure upstream thereof;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the first flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject. - View Dependent Claims (74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86)
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87. A device for delivering a substance to the nasal airway of a subject, comprising:
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a flow resistor against which the subject in use exhales such as to cause closure of the oropharyngeal velum of the subject; and
a delivery unit for delivering a substance in a gas flow to one of the nostrils of the subject, wherein the delivery unit comprises a nosepiece including an outlet through which the substance and gas flow is in use delivered to the one nostril and a sealing member configured to provide a fluid tight seal between the one nostril to the outlet on insertion into the one nostril and maintain the fluid tight seal during operation of the device. - View Dependent Claims (88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103)
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104. A device for delivering a substance to the nasal airway of a subject, comprising:
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a flow resistor against which the subject in use exhales such as to cause closure of the oropharyngeal velum of the subject; and
a delivery unit for delivering a substance in a gas flow to one of the nostrils of the subject, wherein the delivery unit comprises a nosepiece including an outlet through which the substance and gas flow is in use delivered to the one nostril and a sealing member configured to provide a fluid tight seal between the one nostril to the outlet, and the device is configured to maintain a positive pressure in the nasal airway of at least 50 cm H2O. - View Dependent Claims (105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121)
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122. A nasal delivery device for delivering a substance to the nasal airway of a subject, comprising:
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a first flow resistor through which the subject in use exhales such as to closure of the oropharyngeal velum of the subject;
a delivery unit for delivering a substance in a gas flow to one of the nostrils of the subject at a driving pressure which would be such as to cause the gas flow to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril; and
an outlet unit comprising a nosepiece for fitting in the other nostril and a second flow resistor for providing a flow resistance to the gas flow exiting the other nostril so as in use to maintain a positive pressure upstream thereof. - View Dependent Claims (123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136)
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Specification