Improved Methods and Devices for Concentration and Fractionation of Analytes for Chemical Analysis including Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry (MS)
First Claim
Patent Images
1. A device for electrophoretically separating, concentrating, and capturing an analyte in a sample comprising:
- a sample well for retaining a fluid sample in an electrolyte;
a separation layer providing a path for diffusive ionic, and fluidic communication with the well; and
a capture layer providing a path for diffusive ionic, and fluidic communication with the separation layer.
1 Assignment
0 Petitions
Accused Products
Abstract
A device for pre-concentration and purification of analytes from biological samples, such as human serum, to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.
-
Citations
39 Claims
-
1. A device for electrophoretically separating, concentrating, and capturing an analyte in a sample comprising:
-
a sample well for retaining a fluid sample in an electrolyte;
a separation layer providing a path for diffusive ionic, and fluidic communication with the well; and
a capture layer providing a path for diffusive ionic, and fluidic communication with the separation layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 34)
-
-
23. A device for capturing a sample analyte for analysis in a mass spectrometer comprising:
-
a cartridge capture slide comprising a plurality of apertures disposed therein;
a plurality of capture layers disposed in the plurality of apertures. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33)
-
-
35. A cartridge capture slide adaptable for use in a mass spectrometer comprising:
-
an array of apertures disposed in the cartridge capture slide; and
an array of capture layers disposed in the array of apertures, wherein the cartridge capture slide is incorporated within a device comprising an array of sample wells and a cartridge gel plate, and wherein the cartridge gel plate comprises an array of apertures in which are disposed an array of separation layers. - View Dependent Claims (36, 37, 38, 39)
-
Specification