Optimized sensor geometry for an implantable glucose sensor
First Claim
1. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
- a body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, wherein the body comprises a first surface and a second surface, wherein the sensor region is situated at a position on said first surface offset from a center point of said first surface, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body.
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Abstract
An implantable sensor for use in measuring a concentration of an analyte such as glucose in a bodily fluid, including a body with a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region. The body is partially or entirely curved, partially or entirely covered with an anchoring material for supporting tissue ingrowth, and designed for subcutaneous tissue implantation. The geometric design, including curvature, shape, and other factors minimize chronic inflammatory response at the sensing region and contribute to improved performance of the sensor in vivo.
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Citations
25 Claims
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1. An implantable sensor for use in measuring a concentration of an analyte in a bodily fluid, the sensor comprising:
a body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of the body such that when a foreign body capsule forms around the sensor, a contractile force is exerted by the foreign body capsule toward the sensing region, wherein the body comprises a first surface and a second surface, wherein the sensor region is situated at a position on said first surface offset from a center point of said first surface, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A wholly implantable sensor adapted to measure a concentration of an analyte in a bodily fluid, comprising:
a wholly implantable body comprising a sensing region adapted for transport of analytes between the sensor and the bodily fluid, wherein the sensing region is located on a curved portion of a first major surface of said body, wherein the body further comprises a second major surface, wherein the sensing region is situated at a position on said first major surface offset from a center point of said first major surface, wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body, and wherein said first surface comprises a porous material thereon for supporting tissue ingrowth.
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25. An implantable sensor adapted to measure a concentration of an analyte in a bodily fluid, comprising:
a body having a first major surface and, opposite thereto, a second major surface, wherein the first major surface is generally planar, slightly convex, and has rounded edges, with a sensor region located on the first major surface that is spaced away from the rounded edges and offset from a center point of said first major surface, wherein the first major surface is sufficiently convex that when a foreign body capsule forms around the sensor, contractile forces are exerted thereby generally uniformly towards the sensing region, and wherein the sensor is a subcutaneous sensor suitable for implantation in a soft tissue of a body.
Specification