Nasal delivery device
5 Assignments
0 Petitions
Accused Products
Abstract
A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.
160 Citations
70 Claims
-
1-34. -34. (canceled)
-
35. A device for delivering a substance to the nasal airway of a subject, comprising:
-
a flow resistor; and
a nosepiece shaped and sized for insertion into a nostril of the subject to create a fluid tight seal with the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject, and the device is configured to deliver a substance entrained in a gas flow having a flow rate in the nasal airway of at least 20 litres per minute. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44)
-
-
45. A device for delivering a substance to the nasal airway of a subject, comprising:
-
a flow resistor; and
a nosepiece shaped and sized for insertion into a nostril of the subject to create a fluid tight seal with the nostril, the nosepiece comprising an outlet through which a substance may be delivered into the nasal airway of the subject;
wherein the device is configured to create a positive pressure differential between the oral cavity of the subject and the nasal airway of the subject when the subject exhales against the flow resistor, thereby indirectly achieving closure of the oropharyngeal velum of the subject, and the device is configured to deliver a substance entrained in a gas flow having a flow rate in the nasal airway in the range of about 10 to 20 litres per minute. - View Dependent Claims (46, 47, 48, 49, 50, 51, 52, 53, 54)
-
- 55. A device for delivering a substance to the nasal airway of a subject, comprising a delivery unit for delivering a substance in a gas flow to one of the nostrils of the subject, wherein the delivery unit comprises a nosepiece including an outlet through which the substance and gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet, and the delivery unit is configured to deliver the gas flow at a flow rate of at least 20 litres per minute.
Specification