Apparatus for treating asthma using neurotoxin

• US 20060225742A1
• Filed: 06/01/2006
• Published: 10/12/2006
• Est. Priority Date: 05/13/2003
• Status: Abandoned Application

• Current Assignee: Innovative Pulmonary Solutions, Incorporated
• Original Assignee: The Foundry Inc.
• Inventors: Gifford, Hanson S. III, Deem, Mark E.
• Application Number:
  US11/446,043
• Publication Number:
  US 20060225742A1
• Time in Patent Office: Days
• US Class Current: 128/207.140
• CPC Class Codes: A61B 1/018 for receiving instruments
• CPC Class Codes: A61B 1/04 combined with photographic or television appliances
• CPC Class Codes: A61B 1/0661 Endoscope light sources
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 16/00 Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes stimulating the respiratory movement by mechanical, pneumatic or electrical means, iron lungs combined with gas breathing means A61H31/00
• CPC Class Codes: A61M 2025/0086 the needles having bent tips, i.e. the needle distal tips are angled in relation to the longitudinal axis of the catheter
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2202/049 Toxic
• CPC Class Codes: A61M 2210/1035 Bronchi
• CPC Class Codes: A61M 25/0084 being one or more injection needles
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 5/1452 pressurised by means of pistons
• CPC Class Codes: A61M 5/162 Needle sets, i.e. connections by puncture between reservoir and tube ; Connections between reservoir and tube in jet-action syringes A61M5/30; connectors for tubes having sealed ends and a needle for piercing them A61M39/14
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

Apparatus for providing intrabronchial delivery of neurotoxins to control the effects of asthma comprises a shaft having proximal and distal ends and a neurotoxin applicator assembly disposed on the distal end. The neurotoxin applicator assembly comprises a deployable needle assembly, a rotating needle assembly, and a needle-less injection assembly or a nebulizer assembly.

Claims

1. Apparatus for intrabronchial delivery of medication to treat lung disease, the apparatus comprising:

a shaft having a proximal end including at least one inlet port, a distal end and a lumen extending between the inlet ports and the distal end; and

a medication applicator comprising a needle assembly disposed on the distal end of the shaft in fluid communication with the lumen.

2. The apparatus of claim 1, wherein the needle assembly has a retracted delivery position and a deployed position wherein at least one needle extends radially outward from the shaft to penetrate bronchial tissue.

3. The apparatus of claim 1, wherein the needle assembly comprises a wheel having a circumference and a plurality of needles disposed around the circumference, wherein the plurality of needles are in fluid communication with the lumen of the shaft.

4. The apparatus of claim 3, wherein the wheel further comprises a hub that forms an axis of rotation for the wheel.

5. The apparatus of claim 3, wherein the wheel is adapted to be rolled across a target treatment area within a patient'"'"'s bronchial airways.

6. The apparatus of claim 5, wherein the needle assembly further comprises a fender that protects an area of the patient'"'"'s bronchial'"'"' airways opposite the target treatment area.

7. The apparatus of claim 1, further comprising a deflection means disposed on the shaft to position, the port adjacent to the target treatment area.

8. The apparatus of claim 7, wherein the deflection means is an inflatable balloon.

9. A system comprising the apparatus of claim 1, further comprising a bronchoscope having proximal and distal ends, a lumen extending therebetween, wherein the shaft is dimensioned to slidably pass through the lumen of the bronchoscope.