Method and apparatus for blood separations
First Claim
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1. A method for separating blood comprising:
- drawing a first volume of whole blood from a source;
processing said first volume of whole blood through a continuous-flow centrifuge disk, the continuous-flow centrifuge disk including an inner disk wall;
an outer disk wall; and
a separation channel therebetween, including;
an inner surface, an outer surface, an inlet port to introduce whole blood into said separation channel, a first outlet port to remove concentrated red blood cells from said separation channel, a second outlet port to remove plasma from said separation channel, and wherein said inner surface and said outer surface of said separation channel are each independently configured at an angle relative to a spin axis;
collecting a first volume of leukoreduced red blood cells;
collecting a first volume of plasma;
returning the first volume of plasma to the source;
drawing a final volume of whole blood from the source;
processing said final volume of whole blood through the continuous-flow centrifuge disk; and
collecting a final volume of leukoreduced red blood cells.
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Abstract
Described herein is a method and apparatus for collecting and separating whole blood into its components, including collecting an amount of leukoreduced red blood cells. The collection and separation system includes a console and a disposable set. The method may include processing the blood through the centrifuge, collecting the leukoreduced red blood cells, and collecting and returning plasma to the source. The disposable set may include a manifold, a CFC, and various components attached by tubing. These components may include one or more solution bags, blood product bags, bacterial filters, leukofilters, and a donor blood collection tube with access needle.
65 Citations
28 Claims
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1. A method for separating blood comprising:
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drawing a first volume of whole blood from a source;
processing said first volume of whole blood through a continuous-flow centrifuge disk, the continuous-flow centrifuge disk including an inner disk wall;
an outer disk wall; and
a separation channel therebetween, including;
an inner surface, an outer surface, an inlet port to introduce whole blood into said separation channel, a first outlet port to remove concentrated red blood cells from said separation channel, a second outlet port to remove plasma from said separation channel, and wherein said inner surface and said outer surface of said separation channel are each independently configured at an angle relative to a spin axis;
collecting a first volume of leukoreduced red blood cells;
collecting a first volume of plasma;
returning the first volume of plasma to the source;
drawing a final volume of whole blood from the source;
processing said final volume of whole blood through the continuous-flow centrifuge disk; and
collecting a final volume of leukoreduced red blood cells. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for separating whole blood into its constituent parts, comprising:
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collecting whole blood from a source;
processing a first volume of said whole blood through a continuous-flow centrifuge disk;
collecting a first volume of leukoreduced red blood cells from the first volume of said whole blood;
returning a first volume of plasma from the first volume of whole blood to the donor;
processing a second volume of said whole blood through the continuous-flow centrifuge disk;
collecting a second volume of leukoreduced red blood cells from the second volume of said whole blood;
returning a second volume of plasma from the second volume of whole blood to the donor;
processing additional whole blood through the continuous-flow centrifuge disk and collecting the separated leukoreduced red blood cells, until a desired third volume of leukoreduced red blood cells has been collected.
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19. An apparatus for separating blood into its components comprising:
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a needle to draw whole blood from a source, a continuous-flow centrifuge disk to process the whole blood, the continuous-flow centrifuge disk including an inner disk wall;
an outer disk wall; and
a separation channel therebetween, including;
an inner surface, an outer surface, an inlet port to introduce whole blood into said separation channel, a first outlet port to remove concentrated red blood cells from said separation channel, a second outlet port to remove plasma from said separation channel, wherein said inner surface and said outer surface of said separation channel are each independently configured at an angle relative to a spin axis;
a first collection reservoir to collect a first volume and a final volume of leukoreduced red blood cells;
a second collection reservoir to collect a first volume of plasma;
tubing fluidly connecting the needle, the first collection reservoir, and the second collection reservoir to the continuous-flow centrifuge disk;
a pump on tubing between the second collection reservoir and the continuous-flow centrifuge disk to return the first volume of plasma to the source. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28)
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Specification