Fluid processing device with captured reagent beads
First Claim
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1. A fluid processing device, comprising:
- a substrate;
a plurality of reaction regions disposed in or on the substrate;
at least one channel interconnecting the plurality of reaction regions, the at least one channel having a cross-sectional area that includes a maximum dimension; and
a plurality of reagent-releasing beads, each reagent-releasing bead being positioned in a respective one of the reaction regions and comprising one or more reaction components for an assay, wherein each of the reagent-releasing beads has a minimum dimension that is greater than the maximum dimension of the channel cross-section.
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Abstract
A fluid processing device, method and system are provided. The fluid processing device can comprise: a substrate; a plurality of reaction regions disposed in or on the substrate; at least one channel interconnecting the plurality of reaction regions, the at least one channel having a cross-sectional area that includes a maximum dimension; and a plurality of reagent-releasing beads. Each reagent-releasing bead can be positioned in a respective one of the reaction regions. Each bead can comprise one or more reaction components for an assay. Each of the reagent-releasing beads can have a minimum dimension that is greater than the maximum dimension of the channel cross-section.
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Citations
26 Claims
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1. A fluid processing device, comprising:
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a substrate;
a plurality of reaction regions disposed in or on the substrate;
at least one channel interconnecting the plurality of reaction regions, the at least one channel having a cross-sectional area that includes a maximum dimension; and
a plurality of reagent-releasing beads, each reagent-releasing bead being positioned in a respective one of the reaction regions and comprising one or more reaction components for an assay, wherein each of the reagent-releasing beads has a minimum dimension that is greater than the maximum dimension of the channel cross-section. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A fluid processing device, comprising:
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a substrate; and
a pathway disposed in or on the substrate comprising;
a loading port, a vent, a first fluid retainment region comprising a reagent-releasing bead in fluid communication with the loading port, a second fluid retainment region comprising a reagent-releasing bead in fluid communication with the vent, and a first channel in fluid communication with the first fluid retainment region and the second fluid retainment region.
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22. A method comprising:
loading a fluid processing device with a fluid, wherein the fluid processing device comprises a plurality of reaction regions disposed on or in a substrate, interconnected by at least one channel, and each reaction region comprises a reagent-releasing bead comprising a reagent. - View Dependent Claims (23, 24, 25, 26)
Specification