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Multivalent metal salts of boronic acids

  • US 20060229257A1
  • Filed: 05/22/2006
  • Published: 10/12/2006
  • Est. Priority Date: 09/09/2002
  • Status: Abandoned Application
First Claim
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1. A pharmaceutical formulation adapted for oral administration and comprising a) a first species selected from the group consisting of a boronic acid of formula (III), said acid when in the form of a boronate ion thereof, an equilibrium form of said boronic acid and of said boronate ion, and combinations thereof:

  • embedded imagewherein Y comprises a moiety which, together with the aminoboronic acid residue —

    NHCH(R9)—

    B(OH)2, has affinity for the substrate binding site of thrombin; and

    R9 is a straight chain alkyl group interrupted by one or more ether linkages and in which the total number of oxygen and carbon atoms is 3, 4, 5 or 6 or R9 is —

    (CH2)m

    W where m is from 2, 3, 4 or 5 and W is —

    OH or halogen; and

    (b) a second species selected from the group consisting of multivalent metal ions.

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