Cellulosic-based interference domain for an analyte sensor
First Claim
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1. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
- at least one electroactive surface; and
a membrane system disposed on the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the interference domain is configured to resist passage therethrough of at least one interferent, and wherein an equivalent glucose signal response of the at least one interferent is less than about 30 mg/dL.
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Abstract
The present invention relates generally to devices for measuring an analyte in a host. More particularly, the present invention relates to devices for measurement of glucose in a host that incorporate a cellulosic-based interference domain.
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Citations
46 Claims
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1. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
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at least one electroactive surface; and
a membrane system disposed on the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the interference domain is configured to resist passage therethrough of at least one interferent, and wherein an equivalent glucose signal response of the at least one interferent is less than about 30 mg/dL. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 32)
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16. A method for forming an electrochemical sensor for measuring an analyte in a host, the method comprising the steps of:
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providing at least one electroactive surface;
forming a membrane system on the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the interference domain is configured to resist passage therethrough of interfering species; and
exposing the interference domain to ionizing radiation, whereby the interference domain is crosslinked, and whereby an electrochemical sensor is obtained. - View Dependent Claims (17, 18, 19, 20)
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21. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
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at least one electroactive surface; and
a membrane system disposed on the electroactive surface, wherein the membrane system comprises at least one cellulosic derivative and an electrode domain comprising a hydrophilic polymer, and wherein the electrochemical break-in time is not more than about 40 minutes. - View Dependent Claims (22, 23, 24)
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25. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
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at least one electroactive surface; and
a membrane system disposed over the electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the interference domain is configured to resist passage therethrough of at least one interferent. - View Dependent Claims (26, 27, 28, 29, 30, 31, 33, 34, 35, 36, 37)
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38. A method for forming an electrochemical sensor for measuring an analyte in a host, the method comprising the steps of:
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forming a membrane system over an electroactive surface, wherein the membrane system comprises an interference domain comprising at least one cellulosic derivative, wherein the interference domain is configured to resist passage therethrough of at least one interfering species; and
exposing the interference domain to ionizing radiation, whereby the interference domain is crosslinked, and whereby an electrochemical sensor is obtained. - View Dependent Claims (39, 40, 41, 42)
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43. An electrochemical analyte sensor for measuring an analyte in a host, the sensor comprising:
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at least one electroactive surface; and
a membrane system disposed on the electroactive surface, wherein the membrane system comprises at least one cellulosic derivative and an electrode domain, wherein the electrode domain comprises a hydrophilic polymer, and wherein an electrochemical break-in time is not more than about 40 minutes for the sensor. - View Dependent Claims (44, 45, 46)
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Specification