Delivery of alprazolam, estazolam, midazolam or triazolam through an inhalation route
First Claim
1. A composition for delivery of alprazolam consisting of a condensation aerosol a) formed by volatilizing a thin layer of alprazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of alprazolam and condensing the heated vapor of alprazolam to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% alprazolam degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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Abstract
The present invention relates to aerosols containing alprazolam, estazolam, midazolam or triazolam that are used in inhalation therapy. In a method aspect of the present invention, alprazolam, estazolam, midazolam or triazolam is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of alprazolam, estazolam, midazolam or triazolam, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% drug degradation products. In a kit aspect of the present invention, a kit for delivering alprazolam, estazolam, midazolam or triazolam through an inhalation route is provided which comprises: a) a thin coating of an alprazolam, estazolam, midazolam, or triazolam composition and b) a device for dispensing said thin coating as a condensation aerosol.
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Citations
28 Claims
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1. A composition for delivery of alprazolam consisting of a condensation aerosol
a) formed by volatilizing a thin layer of alprazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of alprazolam and condensing the heated vapor of alprazolam to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% alprazolam degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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5. A composition for delivery of estazolam consisting of a condensation aerosol
a) formed by volatilizing a thin layer of estazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of estazolam and condensing the heated vapor of estazolam to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% estazolam degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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9. A composition for delivery of midazolam consisting of a condensation aerosol
a) formed by volatilizing a thin layer of midazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of midazolam and condensing the heated vapor of midazolam to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% midazolam degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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13. A composition for delivery of triazolam consisting of a condensation aerosol
a) formed by volatilizing a thin layer of triazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of triazolam and condensing the heated vapor of triazolam to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% triazolam degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
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17. A method of producing alprazolam in an aerosol form comprising:
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a. heating a thin layer of alprazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the alprazolam to form a heated vapor of the alprazolam, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the alprazolam comprising less than 5% alprazolam degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (18, 19)
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20. A method of producing estazolam in an aerosol form comprising:
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a. heating a thin layer of estazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the estazolam to form a heated vapor of the estazolam, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the estazolam comprising less than 5% estazolam degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (21, 22)
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23. A method of producing midazolam in an aerosol form comprising:
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a. heating a thin layer of midazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the midazolam to form a heated vapor of the midazolam, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the midazolam comprising less than 5% midazolam degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (24, 25)
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26. A method of producing triazolam in an aerosol form comprising:
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a. heating a thin layer of triazolam on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the triazolam to form a heated vapor of the triazolam, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the triazolam comprising less than 5% triazolam degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (27, 28)
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Specification