Compositions and methods of therapy
First Claim
1. A method of inducing tolerance to an antigen in a patient, the method comprising administering to the patient an agent which raises the effective cAMP concentration in a monocyte cell and granulocyte-macrophage colony stimulating factor (GMCSF) or a derivative thereof.
1 Assignment
0 Petitions
Accused Products
Abstract
A method of inducing tolerance to an antigen in a patient, the method comprising administering to the patient an agent which raises the effective cAMP concentration in a monocyte cell and GMCSF or a derivative thereof. Preferably, the agent which raises the effective cAMP concentration in a monocyte cell is a prostaglandin or agonist thereof which stimulates cAMP production in a monocyte. Optionally, the antigen to which it is desired to induce tolerance, or a derivative thereof, may also be administered.
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Citations
80 Claims
- 1. A method of inducing tolerance to an antigen in a patient, the method comprising administering to the patient an agent which raises the effective cAMP concentration in a monocyte cell and granulocyte-macrophage colony stimulating factor (GMCSF) or a derivative thereof.
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11. (canceled)
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15. (canceled)
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17-19. -19. (canceled)
- 36. A composition comprising an agent which raises the effective cAMP concentration in a monocyte cell and granulocyte-macrophage colony stimulating factor (GMCSF) or a derivative thereof.
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46. (canceled)
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50. (canceled)
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52-65. -65. (canceled)
- 66. A therapeutic system for inducing tolerance to an antigen in a patient, the system comprising an agent which raises the effective cAMP concentration in a monocyte cell and GMCSF or a derivative thereof.
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68. (canceled)
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70-72. -72. (canceled)
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76-77. -77. (canceled)
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80-81. -81. (canceled)
Specification