Osmotic dosage form
First Claim
6-1. A dosage form according to claim 6 wherein at least one passageway is provided through the shell to the osmotic chamber.
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Accused Products
Abstract
The present invention is directed to a modified release dosage form for delivering at least one pharmaceutically active ingredient. The dosage form has a first immediate release core for an active ingredient and an osmotic core or osmotic chamber containing at least one pharmaceutically active ingredient that can be the same or a different active ingredient contained in the first immediate release core. A shell having one or more portions surrounds the first immediate release core and osmotic core/chamber. The osmotic chamber includes a barrier layer that is substantially impermeable to the pharmaceutically active ingredient contained therein.
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Citations
27 Claims
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6-1. A dosage form according to claim 6 wherein at least one passageway is provided through the shell to the osmotic chamber.
- 11. A dosage form comprising a first immediate release core containing at least one pharmaceutically active ingredient, an osmotic core containing at least one pharmaceutically active ingredient that is the same or different from the pharmaceutically active ingredient provided in the first immediate release core, and a unitary shell that conforms and coats at least a substantial portion of the first immediate release core and the osmotic core, wherein a portion of the shell provided over the immediate release core is sufficiently thin that it ruptures upon swelling of the immediate release core to release the active contained therein.
- 16. A dosage form comprising a first immediate release core containing a pharmaceutically active ingredient, an osmotic chamber containing one pharmaceutically active ingredient that is the same or different from the pharmaceutically active ingredient provided in the first core, and a shell that consists essentially of an immediate release material and coats at least a substantial portion of the first immediate release core and the osmotic chamber, wherein the osmotic chamber comprises a barrier layer that is substantially impermeable to the active ingredient contained therein.
- 21. A dosage form comprising a first core containing a pharmaceutically active ingredient, an osmotic chamber containing one pharmaceutically active ingredient that is the same or different from the pharmaceutically active ingredient provided in the first core, and a shell having distinct, compositionally different portions that coat a substantial portion of the first core and osmotic chamber, wherein the first shell portion that is in contact with the first core provides an immediate release of the pharmaceutically active ingredient in the first core and the second shell portion in contact with the osmotic chamber produces a modified release profile.
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26. A method for preparing a dosage form comprising:
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a) providing a first immediate release core containing at least one pharmaceutically active ingredient and an osmotic core or an osmotic chamber containing at least one pharmaceutically active ingredient that is the same or different from the pharmaceutically active ingredient provided in the first core to shell-forming module, b) providing a shell that conforms and coats at least a substantial portion of both the first immediate release core and the osmotic core or osmotic chamber.
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27. A method for preparing a dosage form comprising:
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a) providing a first immediate release core containing at least one pharmaceutically active ingredient and an osmotic core or an osmotic chamber containing at least one pharmaceutically active ingredient that is the same or different from the pharmaceutically active ingredient provided in the first core to a shell-forming module, b) providing a shell having distinct portions and that conforms and coats at least a substantial portion of both the first immediate release core and the osmotic core or osmotic chamber.
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Specification