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Physiogenomic method for predicting clinical outcomes of treatments in patients

  • US 20060234262A1
  • Filed: 03/08/2006
  • Published: 10/19/2006
  • Est. Priority Date: 12/14/2004
  • Status: Active Grant
First Claim
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1. A physiogenomics method for predicting an individual'"'"'s response to the environment comprising:

  • (a) selecting a plurality of genetic markers based on an analysis of the entire human genome or a fraction thereof;

    (b) identifying significant covariates among demographic data and the other phenotypes by principal component analysis;

    (c) performing for each selected genetic marker an unadjusted association test using genetic data (d) using permutation testing to obtain a non-parametric and marker complexity probability value for identifying significant genetic markers;

    and (e) constructing a physiogenomic model by linear regression analyses and model parameterization for the dependence of said patient'"'"'s response to treatment with respect to said genetic markers; and

    (f) identifying one or more genes not associated with a particular outcome in said patient to serve as a physiogenomic control.

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