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Implantable biosensor

  • US 20060234369A1
  • Filed: 11/08/2005
  • Published: 10/19/2006
  • Est. Priority Date: 04/14/2005
  • Status: Abandoned Application
First Claim
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1. An implantable biosensor comprising:

  • transgenic electrically excitable mammalian tissue or cells which are augmented with an expression cassette comprising a transcriptional regulatory element operably linked to an open reading frame encoding a protein which is capable of associating with the cell membrane and binding a molecule found in physiological fluid of a mammal, which binding alters the amount and/or activity of one or more intracellular second messenger molecules and which one or more intracellular second messenger molecules in turn modulate the activity of one or more ion channels, wherein the transgenic electrically excitable tissue or cells are optionally coupled via an electrical interface to an electronic measuring device or an electronic amplifying device.

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