Method for the formation of hydrogel multilayers through surface initiated photopolymerization
First Claim
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1. A multiple-layer hydrogel comprising:
- (a) a first layer comprising polyethylene glycol; and
(b) at least one subsequent layer comprising polyethylene, wherein the at least one subsequent layer is covalently attached to the first layer.
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Abstract
Multiple-layer hydrogels and methods of forming hydrogels having multiple layers are disclosed. The hydrogels are formed of prepolymerization solutions comprising monomers or macromers, particularly polyethylene glycol. The layers are covalently bonded, and the hydrogels may comprise two or more layers.
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20 Claims
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1. A multiple-layer hydrogel comprising:
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(a) a first layer comprising polyethylene glycol; and
(b) at least one subsequent layer comprising polyethylene, wherein the at least one subsequent layer is covalently attached to the first layer. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of forming a hydrogel comprising:
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(a) preparing a solution;
(b) applying a first layer of the solution to a support surface;
(c) exposing the first layer of solution to radiation; and
(d) applying a second layer of the solution to the first layer. - View Dependent Claims (9, 10, 11, 12, 13)
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14. A method of forming a hydrogel, the method comprising the steps of:
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(a) mixing a prepolymerization solution;
(b) providing a support surface and exposing the surface to a photoinitiator;
(c) depositing a first layer of the prepolymerization solution onto the surface;
(d) exposing the first layer to radiation;
(e) exposing the first layer to the photoinitiator;
(f) depositing a second layer of prepolymerization solution onto the first layer; and
(g) exposing the second layer to radiation. - View Dependent Claims (15, 16, 17, 18, 19, 20)
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Specification