Lubricious eluting polymer blend and coating made from the same
First Claim
1. A guidewire with a drug eluting coating comprising:
- a guidewire body; and
a coating disposed over at least a portion of said guidewire body wherein the coating is a blend of a polyethylene oxide with a molecular weight between about 100,000 and about 8,000,000 and a polyurethane, the blend including up to 60% by weight of the polyethylene oxide, the coating further including a biologically active agent loaded into the blend.
1 Assignment
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Accused Products
Abstract
The present invention relates to a drug eluting polymer blend. More particularly, the present invention relates to a medical device with a drug eluting polymer blend incorporated therein wherein the drug elution rate is controlled by cross-linking the polymer blend. Once formed, the polymer blend can be used to create a medical device by itself or in combination with other materials. The drug, or other biologically active agent, can be loaded into the blend by soaking the polymer blend in a solution containing the agent before, during or after formation of the medical device. Alternatively, the drug or agent can be loaded into one of the polymers of the polymer blend before formation of the blend or during formation of the blend. Likewise, the polymer blend can be cross-linked before or after loading the selected drug or biologically active agent. Upon insertion into the body and exposure to the body'"'"'s fluid, the blend releases the loaded biologically active agent at the desired rate.
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Citations
20 Claims
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1. A guidewire with a drug eluting coating comprising:
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a guidewire body; and
a coating disposed over at least a portion of said guidewire body wherein the coating is a blend of a polyethylene oxide with a molecular weight between about 100,000 and about 8,000,000 and a polyurethane, the blend including up to 60% by weight of the polyethylene oxide, the coating further including a biologically active agent loaded into the blend. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of forming a medical device that releases a biologically active agent over a desired period of time comprising:
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preparing a finely dispersed and substantially uniform polymer blend of polyethylene oxide, the polyethylene oxide molecular weight between about 100,000 and about 8,000,000, and a polyurethane, the blend including up to 60% by weight of the polyethylene oxide;
forming a medical device wherein at least one portion includes the polymer blend; and
loading a biologically active agent into the blend. - View Dependent Claims (8, 9, 10, 11, 12, 13)
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14. A drug eluting polymer comprising:
a finely dispersed blend of a polyethylene oxide with a molecular weight of between about 100,000 and about 8,000,000 and a polyurethane, the blend including up to about 60% by weight of the polyethylene oxide, the blend including a biologically active agent whereby the biologically active agent is released upon exposure to a solvent. - View Dependent Claims (15, 16, 17, 18, 19)
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20. A drug eluting polymer comprising:
a finely dispersed blend of a polyethylene oxide with a molecular weight of between about 100,000 and about 8,000,000 and a polyether block amide, the blend including up to about 60% by weight of the polyethylene oxide, the blend including a biologically active agent whereby the biologically active agent is released upon exposure to a solvent.
Specification