Polymeric micelles for drug delivery
First Claim
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1. A micelle comprising a multiblock copolymer which comprises a polymeric hydrophilic block, a crosslinked poly(amino acid block), and a poly(amino acid block), characterized in that said micelle has an inner core, a crosslinked outer core, and a hydrophilic shell.
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Abstract
The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.
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37 Claims
- 1. A micelle comprising a multiblock copolymer which comprises a polymeric hydrophilic block, a crosslinked poly(amino acid block), and a poly(amino acid block), characterized in that said micelle has an inner core, a crosslinked outer core, and a hydrophilic shell.
- 20. A crosslinked multiblock copolymer of formula III:
- 24. A drug-loaded micelle comprising a multiblock copolymer which comprises a polymeric hydrophilic block, a crosslinked poly(amino acid block), and a poly(amino acid block), characterized in that said rhicelle has a drug-loaded inner core, a crosslinked outer core, and a hydrophilic shell.
Specification