Assay test strips and reading same
First Claim
1. An assay test strip, comprising:
- a flow path for a fluid sample;
a sample receiving zone coupled to the flow path;
a label that specifically binds a target analyte;
s a detection zone coupled to the flow path and comprising a region of interest and an immobilized test reagent that specifically binds the target analyte; and
at least one position marker aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest.
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Accused Products
Abstract
An assay test strip includes a flow path, a sample receiving zone, a label, a detection zone that includes a region of interest, and at least one position marker. The at least one position marker is aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. A diagnostic test system includes a reader that obtains light intensity measurement from exposed regions of the test strip, and a data analyzer that performs at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature.
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Citations
55 Claims
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1. An assay test strip, comprising:
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a flow path for a fluid sample;
a sample receiving zone coupled to the flow path;
a label that specifically binds a target analyte;
s a detection zone coupled to the flow path and comprising a region of interest and an immobilized test reagent that specifically binds the target analyte; and
at least one position marker aligned with respect to the region of interest such that location of the at least one position marker indicates a position of the region of interest. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28)
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29. An assay test strip, comprising:
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a flow path for a fluid sample;
a sample receiving zone coupled to the flow path;
a label that specifically binds a target analyte;
a detection zone coupled to the flow path and comprising an immobilized test reagent that specifically binds the target analyte; and
at least one reference feature exposed for optical inspection and having a calibrated amount of the label.
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30. An assay test strip, comprising:
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a flow path for a fluid sample;
a sample receiving zone coupled to the flow path;
a label that specifically binds a target analyte;
a detection zone coupled to the flow path and comprising a region of interest and an immobilized test reagent that specifically binds the target analyte, wherein the test reagent is immobilized in discrete code areas forming a pattern that encodes information.
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31. A diagnostic test system, comprising:
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a housing comprising a port constructed and arranged to receive a test strip that comprises a flow path for a fluid sample, a sample receiving zone coupled to the flow path, a label that specifically binds a target analyte, a detection zone coupled to the flow path and comprising a test region exposed for optical inspection and having an immobilized test reagent that specifically binds the target analyte, and at least one reference feature;
a reader operable to obtain light intensity measurements from exposed regions of the test strip when the test strip is loaded in the port; and
a data analyzer operable to perform operations comprising at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying at least one operational parameter of the reader based on at least one measurement obtained from the at least one reference feature. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
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44. A diagnostic test method, comprising:
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receiving a test strip that comprises a flow path for a fluid sample, a sample receiving zone coupled to the flow path, a label that specifically binds a target analyte, a detection zone coupled to the flow path and comprising a test region exposed for optical inspection and having an immobilized test reagent that specifically binds the target analyte, and at least one reference feature;
obtaining light intensity measurements from exposed regions of the test strip; and
performing at least one of (a) identifying ones of the light intensity measurements obtained from the test region based on at least one measurement obtained from the at least one reference feature, and (b) generating a control signal modifying the obtaining of light intensity measurements from exposed regions of the test strip based on at least one measurement obtained from the at least one reference feature. - View Dependent Claims (45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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Specification