Methods of treating disorders associated with toll-like receptor 4 (TLR4) signalling
First Claim
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1. A method of treating or preventing a disorder associated with a gram negative bacterial infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a composition comprising an extracellular domain of Toll-Like Receptor 4 (TLR4).
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Abstract
Described herein are methods and compositions for treating, preventing, and diagnosing disorders associated with TLR4 signalling, e.g., gram negative bacterial infection and sterile inflammations such as rheumatoid arthritis.
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17 Claims
- 1. A method of treating or preventing a disorder associated with a gram negative bacterial infection in a subject, the method comprising administering to the subject a therapeutically effective amount of a composition comprising an extracellular domain of Toll-Like Receptor 4 (TLR4).
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10. A method of removing soluble Myeloid Differentiation Antigen-2 (sMD-2) from the blood of a subject, the method comprising:
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removing blood from the subject;
contacting the blood with a composition comprising an extracellular domain of Toll-Like Receptor 4 (TLR4) under conditions and for a time sufficient to bind sMD-2 in the blood to the TLR4, thereby forming TLR4/MD-2 complexes;
removing the TLR4/MD-2 complexes from the blood; and
optionally returning the blood to the subject, thereby removing soluble MD-2 from the blood of the subject. - View Dependent Claims (11, 12, 13, 14)
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- 15. A method of diagnosing a subject with a gram negative bacterial infection, the method comprising measuring levels of soluble Myeloid Differentiation Antigen-2 (sMD-2) in a sample from the subject, wherein an elevated level of sMD-2 as compared to a reference indicates that the subject has a gram negative bacterial infection.
Specification