Methods for improving cell therapy and tissue regeneration in patients with cardiovascular and neurological diseases by means of shockwaves
First Claim
1. A method for improving cell therapy in a patient suffering from at least one of a cardiovascular disease and a neurological disease, comprising the step of treating a tissue of the patient affected by the at least one of the cardiovascular disease and the neurological disease with shock waves, wherein the tissue is targeted for cell therapy.
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Abstract
Improving cell therapy and tissue regeneration in a patient suffering from a cardiovascular or a neurological disease by treating a tissue of the patient with shock waves and/or applying to the patient a therapeutically effective amount of stem cells and/or progenitor cells. Such treatment increases expression of chemoattractants, pro-angiogenic factors, and pro-survival factors. The chemoattractants can be, for example, vascular endothelial growth factor (VEGF) or stromal cell derived factor 1 (SDF-1). For example, the treated tissue can be located in the patient'"'"'s heart or in a skeletal muscle of the patient, and the shock waves can be extracorporeal shock waves (ESW) or intracorporeal shock waves. The cardiovascular disease can have an ischemic or non-ischemic etiology. For example, the cardiovascular disease can be a myocardial infarction, ischemic cardiomyopathy, or a dilatative cardiomyopathy. For example, the neurological disease can be a peripheral neuropathy or neuropathic pain.
34 Citations
55 Claims
- 1. A method for improving cell therapy in a patient suffering from at least one of a cardiovascular disease and a neurological disease, comprising the step of treating a tissue of the patient affected by the at least one of the cardiovascular disease and the neurological disease with shock waves, wherein the tissue is targeted for cell therapy.
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11. A method for improving the tissue regeneration in a patient suffering from at least one of a cardiovascular disease and a neurological disease, comprising the steps of:
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treating a tissue of the patient affected by the at least one of the cardiovascular disease and the neurological disease with shock waves; and
applying to the patient a therapeutically effective amount of at least one of stem cells and progenitor cells. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24)
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25. A method for treating at least one of a cardiovascular disease and a neurological disease in a patient, comprising the steps of:
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treating a tissue of the patient affected by the at least one of the cardiovascular disease and the neurological disease by means of shock waves; and
applying to the patient a therapeutically effective amount of at least one of stem cells and progenitor cells. - View Dependent Claims (26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
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39. A method of using at least one of stem cells and progenitor cells for preparing a pharmaceutical composition for treating a patient suffering from at least one of a cardiovascular disease and a neurological disease, comprising the steps of:
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subjecting a tissue of the patient suffering from the at least one of the cardiovascular disease and the neurological disease to a treatment with shock waves; and
applying to the patient a therapeutically effective amount of at least one of the stem cells and the progenitor cells. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55)
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Specification