Coatings on medical implants to guide soft tissue healing

• US 20060246105A1
• Filed: 04/28/2005
• Published: 11/02/2006
• Est. Priority Date: 04/28/2005
• Status: Active Grant

• Current Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Original Assignee: Warsaw Orthopedic Incorporated (Medtronic Plc)
• Inventors: Felton, Sharonda, Molz, Fred
• Granted Patent: US 8,414,907 B2
• Time in Patent Office: Days
• US Class Current: 424/423
• CPC Class Codes: A61L 2300/412 Tissue-regenerating or healing or proliferative agents
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: C08L 71/02 Polyalkylene oxides

Abstract

Embodiments include coatings or surface treatments for medical instruments, devices, and/or implants that promote soft tissue healing. More particularly, embodiments relate to treating portions of instruments, devices, and implants where tissue healing is desired with tissue healing promoting treatments.

Claims

1. A medical implement comprising a tissue healing promoting treatment on at least a portion of its surface, the tissue healing promoting treatment comprising at least an anti-adhesion agent.

2. The medical implement of claim 1, wherein the tissue healing promoting treatment further comprises an osteoconductive agent or an osteoinductive agent.

3. The medical implement of claim 1, wherein the tissue healing promoting treatment further comprises at least one beneficial additive selected from the group consisting of antibiotics, antiretroviral drugs, anti-inflammatory agents, analgesics, immunosuppressive agents, substances that enhance isotonicity and chemical stability, and mixtures thereof.

4. The medical implement of claim 1, wherein the anti-adhesion agent is a polyethylene glycol based anti-adhesion agent.

5. The medical implement of claim 1, wherein the anti-adhesion agent is a glucosamine based anti-adhesion agent.

6. The medical implement of claim 1, wherein the anti-adhesion agent is selected from the group consisting of alkyd polyesters, materials derived from polyvinyl alcohols, polyhydroxyalkanoate polymers, polyoxyalkylene compositions containing polyethylene oxide (PEO), fluorocarbons, and mixtures thereof.

7. The medical implement of claim 1, wherein the anti-adhesion agent is selected from the group consisting of alginates, cellulose, chitosan, collagen, fibrinogen/fibrin, hyaluronic acid, lactides, phospholipids, polysaccharides, and mixtures thereof.

8. The medical implement of claim 2, wherein the osteoconductive or osteoinductive agent is selected from the group consisting of one or more isolated osteoinductive agents selected from the group consisting of one or more BMPs, one or more VEGFs, one or more CTGFs, one or more GDFs, one or more CDMPs, one or more LMPs, one or more TGF-β

s, and any combination thereof.

9. The medical implement of claim 8, wherein the one or more isolated osteoinductive agents are selected from the group consisting of:

a) BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-15, BMP-16, BMP-17, BMP-18, and any combination thereof;

b) CTGF-1, CTGF-2, CGTF-3, CTGF-4, and any combination thereof;

c) VEGF-A, VEGF-B, VEGF-C, VEGF-D, VEGF-E, and any combination thereof;

d) GDF-1, GDF-2, GDF-3, GDF-7, GDF-10, GDF-11, GDF-15, and any combination thereof;

e) CDMP-1, CDMP-2, LMP-1, LMP-2, LMP-3, and any combination thereof;

f) TGF-β

-1, TGF-α

-2, TGF-β

-3, and any combination thereof; and

g) any combination of one or more members of these groups.

14. A method of performing a spinal surgery comprising:

making an incision in the skin of a patient;

accessing the surgical site using minimally invasive procedures;

preparing the surgical site;

optionally implanting a spinal implant at the surgical site; and

closing the incision,

whereby one or more of the procedures is carried out using the medical implement as claimed in claim 1.

15. The method of claim 14, wherein use of the medical implement results in release of tissue healing promoting formulations to the tissue adjacent the surgical site.

16. The method of claim 14, wherein accessing the surgical site comprises:

placing a guidewire through the incision to the surgical site; and

serially dilating the patient'"'"'s tissue using a series of consecutively larger diameter cannulas to prepare a channel to the surgical site, the channel capable of accepting surgical instruments useful in the surgery.

17. The method of claim 16, wherein the guidewire and each consecutively larger diameter cannula comprises a tissue healing promoting treatment on at least a portion of its surface, the tissue healing promoting treatment comprising at least an anti-adhesion agent.

18. The method of claim 14, wherein preparing the surgical site comprises expanding an expandable member coated with a tissue healing promoting treatment on at least a portion of its surface, the tissue healing promoting treatment comprising at least an anti-adhesion agent.

19. A kit comprising the medical implement of claim 1.

20. The kit of claim 19, wherein the tissue healing promoting treatment and the medical implement are packaged separately.

10. A method of making a medical implement comprising:

forming the medical implement; and

modifying at least a portion of a surface of the medical implement that is intended to contact body tissue with a tissue healing promoting treatment, the tissue healing promoting treatment comprising at least an anti-adhesion agent.

11. The method of claim 10, wherein forming the medical implement includes forming the medical implement such that it has a porous surface on at least a portion of its surface.

12. The method of claim 11, wherein modifying at least a portion of the surface comprises applying a tissue healing promoting formulation to the porous surfaces of the implement.

13. The method of claim 12, wherein applying the tissue healing promoting formulation comprises an application procedure selected from the group consisting of spraying, painting, brushing, immersing the medical implement in a solution comprising the tissue healing promoting formulation.