Antimicrobial pigments

• US 20060246149A1
• Filed: 03/24/2004
• Published: 11/02/2006
• Est. Priority Date: 04/18/2003
• Status: Abandoned Application

• Current Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Original Assignee: Merck Patent GmbH (Merck & Co., Inc.)
• Inventors: Meduski, Jerzy, Buchholz, Herwig, Brunner, Markus, Bicard-Benhamou, Valerie
• Application Number:
  US10/553,668
• Publication Number:
  US 20060246149A1
• Time in Patent Office: Days
• US Class Current: 424/603
• CPC Class Codes: A61K 2800/43 Pigments; Dyes
• CPC Class Codes: A61K 2800/621 by inorganic compounds
• CPC Class Codes: A61K 33/30 Zinc; Compounds thereof
• CPC Class Codes: A61K 33/34 Copper; Compounds thereof
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 8/0241 Containing particulates characterized by their shape and/or structure see also A61K8/04, A61K8/11, and A61K8/14, further aspects are classified in A61K2800/40 and subcodes
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61P 1/02 Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
• CPC Class Codes: A61P 31/04 Antibacterial agents
• CPC Class Codes: A61P 31/22 for herpes viruses
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 15/00 Anti-perspirants or body deodorants deodorisation of air A61L9/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 5/006 Antidandruff preparations
• CPC Class Codes: C01P 2004/20 extending in two dimensions, e.g. plate-like
• CPC Class Codes: C01P 2006/62 L* (lightness axis)
• CPC Class Codes: C01P 2006/63 a* (red-green axis)
• CPC Class Codes: C01P 2006/64 b* (yellow-blue axis)
• CPC Class Codes: C09C 1/0015 Pigments exhibiting interference colours, e.g. transparent platelets of appropriate thinness or flaky substrates, e.g. mica, bearing appropriate thin transparent coatings
• CPC Class Codes: C09C 1/3054 : Coating
• CPC Class Codes: C09C 2200/1004 : the core comprising at least one inorganic oxide, e.g. Al2O3, TiO2 or SiO2
• CPC Class Codes: C09C 2200/102 : the core consisting of glass or silicate material like mica or clays, e.g. kaolin
• CPC Class Codes: C09C 2200/1087 : the core consisting of bismuth oxychloride, magnesium fluoride, nitrides, carbides, borides, lead carbonate, barium or calcium sulfate, zinc sulphide, molybdenum disulphide or graphite
• CPC Class Codes: C09C 2200/302 : Thickness of a layer with high refractive material
• CPC Class Codes: C09C 2200/303 : Thickness of a layer with low refractive material
• CPC Class Codes: C09C 2200/304 : Thickness of intermediate layers adjacent to the core, e.g. metallic layers, protective layers, rutilisation enhancing layers or reflective layers
• CPC Class Codes: C09C 2200/505 : Inorganic particles, e.g. oxides, nitrides or carbides
• CPC Class Codes: C09C 3/06 : Treatment with inorganic compounds C09C3/006, C09C3/048 take precedence
• CPC Class Codes: C09C 3/063 : Coating
• CPC Class Codes: C09D 11/037 : characterised by the pigment
• CPC Class Codes: C09D 5/14 : Paints containing biocides, e.g. fungicides, insecticides or pesticides C09D5/16 takes precedence

Abstract

The present invention relates to antimicrobial pigments, obtainable by agitating a suspension comprising one or more inorganic pigments and an antimicrobial compound, especially silver oxide, and their use in various applications, such as cosmetics, inks, lacquers or plastics.

Claims

1. Antimicrobial pigments, obtainable by agitating a suspension comprising one or more inorganic pigments and silver oxide as antimicrobial compound.

2. Antimicrobial pigments according to claim 1, characterized in that the inorganic pigment is platelet-shaped, spherical or needle-shaped.

3. Antimicrobial pigments according to claim 1, characterized in that the inorganic pigments are inorganic white pigments, inorganic coloured pigments, inorganic black pigments, effect pigments, luminous pigments, magnesium carbonate, mica, SiO₂, TiO₂, aluminium oxide, glass, micaceous iron oxide, oxidised graphite, aluminium oxide-coated graphite, basic lead carbonate, barium sulphate, chromium oxide or MgO.

4. Antimicrobial pigments according to claim 3, characterized in that the effect pigments are based on substrates.

5. Antimicrobial pigments according to claim 4, characterized in that the substrates are selected from the group of natural or synthetic mica, SiO₂, TiO₂, BiOCl, Aluminium oxide, glass, micaceous iron oxide, graphite, oxidised graphite, aluminium oxide coated graphite, basic lead carbonate, barium sulphate, chromium oxide, BN, MgO, magnesium fluoride, Si₃N₄, and/or metals.

6. Antimicrobial pigments according to claim 5, characterized in that the substrates additionally are coated with one or more layers of BiOCl and/or transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxides, metal suboxides, metal oxide hydrates, metals, metal nitrides, metal oxynitrides, metal fluorides and/or mixtures of these materials.

7. Antimicrobial pigments according to claim 6, characterized in that the one or more layers of BiOCl and/or transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxides, metal suboxides, metal oxide hydrates, metals, metal nitrides, metal oxynitrides, metal fluorides and/or mixtures of these materials are arranged as alternating layers of transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxides, metal suboxides, metal oxide hydrates, metals, metal nitrides, metal oxynitrides, metal fluorides and/or mixtures of these materials or BiOCl with a refractive index n>

1.8 and transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxides, metal suboxides, metal oxide hydrates, metals, metal nitrides, metal oxynitrides, metal fluorides and/or mixtures of these materials with a refractive index n≦

1.8.

8. Antimicrobial pigments according to claim 6, characterized in that the outer layer of the inorganic pigment comprises a transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxide, metal suboxide, metal oxide hydrate and/or mixture of these materials.

9. Antimicrobial pigments according to claim 6, characterized in that the transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxides, metal suboxides, metal oxide hydrates, metals, metal nitrides, metal oxynitrides, metal fluorides and/or mixtures of these materials additionally contain organic and/or inorganic colorants or elements as dopant.

10. Antimicrobial pigments according to claim 1, characterized in that the inorganic pigment comprises spherical particles or spherical capsules of metal oxides, BiOCl, magnesium carbonate, graphite, oxidised graphite, aluminium oxide-coated graphite, basic lead carbonate, barium sulphate, BN, magnesium fluoride, Si₃N₄ and/or metals.

11. Antimicrobial pigments according to claim 10, characterized in that the spherical particles or capsules are coated with one or more layers of transparent, semitransparent or opaque, selectively or nonselectively absorbing or nonabsorbing metal oxides, metal suboxides, metal oxide hydrates, metals, metal nitrides, metal oxynitrides, metal fluorides and/or mixtures of these materials.

12. Antimicrobial pigments according to claim 1, characterized in that they are additionally coated with a protective coating layer.

13. Antimicrobial pigments according to claim 12, characterized in that the protective coating is selected from silica, silicates, borosilicates, aluminosilicates, alumina, aluminum phosphate, or mixtures thereof.

14. Antimicrobial pigments according to claim 1, characterized in that L, a and b values of the employed inorganic pigments and the antimicrobial pigments have a maximum deviation for the L value of −

6≦

Δ

L≦

6, for the a value of −

5≦

Δ

a≦

5 and for the b value of −

5≦

Δ

b≦

5.

15. Antimicrobial pigments according to claim 1, characterized in that the silver oxide is substituted by silver halogenide, silver nitrate, silver sulfate, silver carboxylates, silver carbonate, silver citrate, copper oxides, copper sulfide, copper nitrate, copper carbonate, copper sulftate, copper halogenides, copper carboxylates, zinc oxide, zinc sulfide, zinc silicate, zinc acetate, zinc chloride, zinc nitrate, zinc sulfate, zinc gluconate, zinc citrate, zinc phosphate, zinc propionate, zinc salicylate, zinc lactate, zinc oxalate, zinc iodate, zinc iodide or combinations thereof.

16. Antimicrobial pigments according to claim 1, characterized in that the amount of the antimicrobial compound is in the range of 0.001 to 10% by weight, preferably between 0.005 and 5% by weight, based on the inorganic pigment.

25. Use of antimicrobial pigments according to claim 1 for the inhibition of the growth and/or progeny of microorganisms.

26. Use of pigments according to claim 1 in formulations or applications.

27. Use according to claim 26, characterized in that the formulation and/or application is selected from the group of cosmetic formulations, paints, inks, food colouring, home care products, animal care products, products for personal and work hygiene, contact lenses, chromatography materials, medical equipment, protective topicals, pharmaceutical, especially dermatological formulations, lacquers, coatings and/or plastics.

28. Use according to claim 26 characterized in that the antimicrobial pigments are in combination with preservatives and antimicrobial agents.

29. Use according to claim 26 characterized in that the antimicrobial pigments are in combination with antibiotics.

30. Use according to claim 29, characterized in that the antibiotics are selected from the group of Beta-lactam, Vancomycin, Macrolides, Tetracyclines, Quinolones, Fluoroquinolones, Nitrated compounds, Aminoglycosides, Phenicols, Lincosamids, Synergistins, Fosfomycin, Fusidic acid, oxazolidinones, Rifamycins, Polymixynes, Gramicidins, Tyrocydine, Glycopeptides, Sulfonamides or Trimethoprims

31. Use of antimicrobial pigments according to claim 1 for oral care.

32. Use of antimicrobial pigments according to claim 1 for the prophylaxis and/or treatment of herpes.

33. Formulations and/or applications comprising antimicrobial pigments according to claim 1.

34. Formulations or applications according to claim 33, characterized in that the formulation comprises at least one compound selected from the group consisting of suitable substrates for microorganisms, wherein the suitable substrate for microorganisms is preferably selected from the group consisting of alkanes, alkenes, alkines, with or without functional groups, sugars, polyols, alcohols, saturated or unsaturated carboxylic acids, proteins, amino acids, water, fatty acids, waxes, fats, mineral oils, salts, hormones, steroids, vitamins and/or derivatives or salts thereof.

17. Method for the preparation of antimicrobial pigments comprising the agitation of a suspension comprising one or more inorganic pigments and silver oxide as antimicrobial compound.

18. Method according to claim 17, characterized in that the preparation is performed in water, ethanol, methanol, 1-propanol, 2-propanol and/or mixtures thereof.

19. Method according to claim 17, characterized in that the preparation temperature is between 10 and 60°

C.

20. Method according to claim 17, characterized in that the silver oxide is substituted by silver halogenide, silver nitrate, silver sulfate, silver carboxylates, silver carbonate, silver citrate, copper oxides, copper sulfide, copper nitrate, copper carbonate, copper sulfate, copper halogenides, copper carboxylates, zinc oxide, zinc sulfide, zinc silicate, zinc acetate, zinc chloride, zinc nitrate, zinc sulfate, zinc gluconate, zinc citrate, zinc phosphate, zinc propionate, zinc salicylate, zinc lactate, zinc oxalate, zinc iodate, zinc iodide or combinations thereof.

21. Method according to claim 17, characterized in that the amount of the antimicrobial compound is in the range of 0.001 to 10% by weight, preferably between 0.005 and 5% by weight, based on the inorganic pigment.

22. Method according to claim 17, characterized in that the antimicrobial pigments are further coated with a protective coating layer.

23. Method according to claim 22, characterized in that the protective coating is selected from silica, silicates, borosilicates, aluminosilicates, alumina, aluminum phosphate, or mixtures thereof.

24. Method according to claim 22, characterized in that the coating is performed wet-chemically.