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In-vitro method for the production of a homologous stented tissue-engineered heart valve

  • US 20060246584A1
  • Filed: 09/04/2002
  • Published: 11/02/2006
  • Est. Priority Date: 08/01/2002
  • Status: Abandoned Application
First Claim
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1. An in vitro method for the production of a homologous heart valve, comprising the steps of:

  • a) providing a biodegradable support, b) colonizing the support with homologous fibroblasts or myofibroblasts cells or a combination thereof to form a connective tissue matrix, c) optionally colonizing the connective tissue matrix with endothelial cells, and d) fixing the connective tissue matrix to a non-degradable or poorly degradable frame construction, wherein, before or after the fixing of the frame construction, the connective tissue matrix optionally colonized with endothelial cells is introduced into a pulsatile flow chamber in which it can be exposed to increasing flow rates, and the flow rate is increased continuously or discontinuously.

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