Method of improving learning and memory in mammals

• US 20060247153A1
• Filed: 04/29/2005
• Published: 11/02/2006
• Est. Priority Date: 04/29/2005
• Status: Abandoned Application

• Current Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC), University of Sydney
• Original Assignee: Mead Johnson Nutrition Company (Reckitt Benckiser Group PLC)
• Inventors: Wang, Bing, Brand-Miller, Jennie, McMahon, Robert J., Rumsey, Steven Charles
• Application Number:
  US11/118,790
• Publication Number:
  US 20060247153A1
• Time in Patent Office: Days
• US Class Current: 514/5.700
• CPC Class Codes: A23L 33/185 Vegetable proteins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/322 having an effect on the health of the nervous system or on mental function
• CPC Class Codes: A23V 2250/54246 Casein
• CPC Class Codes: A61K 31/70 Carbohydrates; Sugars; Derivatives thereof sorbitol A61K31/047
• CPC Class Codes: A61K 38/14 Peptides containing saccharide radicals; Derivatives thereof , e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
• CPC Class Codes: A61K 38/1709 from mammals
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Abstract

A method of improving learning and/or memory behavior in a mammal is described which involves administering to the mammal casein glycomacropeptide in an amount sufficient to improve learning and/or memory behavior in the mammal.

Claims

1. A method of improving learning and/or memory behavior in a mammal in need of improvement in learning and/or memory behavior, the method comprising administering to the mammal casein glycomacropeptide in an amount sufficient to improve learning and/or memory behavior in the mammal.

2. The method according to claim 1, wherein the mammal is between about 1 day and about 4 years of age.

3. The method according to claim 1, wherein the mammal is a neonatal mammal.

4. The method according to claim 1, wherein the need of improvement in learning and/or memory behavior is shown where at least a portion of the mammal'"'"'s nutritional requirement has been supplied by a formula having less than about 100 mg/L of sialic acid.

5. The method according to claim 1, wherein the need of improvement in learning and/or memory behavior is shown where substantially all of the mammal'"'"'s nutritional requirement has been supplied by administration of a formula having less than about 100 mg/L of sialic acid.

6. The method according to claim 4, wherein a major part of the protein contained in the formula is soy protein or cow'"'"'s milk protein.

7. The method according to claim 6, wherein at least about 75% by weight of the protein contained in the formula is soy protein or cow'"'"'s milk protein.

8. The method according to claim 6, wherein substantially all of the protein contained in the formula is soy protein or cow'"'"'s milk protein.

9. The method according to claim 1, wherein the need of improvement in learning and/or memory behavior is shown where the mammal'"'"'s nutritional requirement has been supplied by a diet providing sialic acid in an amount that is lower than would normally be obtained from breastfeeding.

10. The method according to claim 9, wherein the diet providing a lower amount of sialic acid than would normally be obtained from breastfeeding comprises a liquid formula having a sialic acid content that is below about 100 mg/L.

11. The method according to claim 9, wherein the diet providing a lower amount of sialic acid than would normally be obtained from breastfeeding comprises a liquid formula having a sialic acid content that is below about 200 mg/L.

12. The method according to claim 1, wherein administering the formula comprises enteral administration.

13. The method according to claim 1, wherein the casein glycomacropeptide is included in a formula that is an infant formula.

14. The method according to claim 13, wherein the formula is a nutritionally complete infant formula comprising carbohydrate, lipid, and protein.

15. The method according to claim 14, wherein the protein comprises a material that is selected from cow'"'"'s milk protein, soy protein, and mixtures thereof.

16. The method according to claim 1, wherein the casein glycomacropeptide is administered in an amount sufficient to provide at least about 100 mg/kg/day of sialic acid to the mammal.

17. The method according to claim 1, wherein the casein glycomacropeptide is administered in an amount sufficient to provide at least about 200 mg/kg/day of sialic acid to the mammal.

18. The method according to claim 13, wherein the formula comprises a liquid having a sialic acid concentration of at least about 200 mg/liter.

19. The method according to claim 18, having a sialic acid level of at least about 300 mg/liter.

20. The method according to claim 18, having a sialic acid level of at least about 600 mg/liter.

21. The method according to claim 1, comprising a formula having a total protein content of between 12 and 16 grams/liter of which no more than 40% by weight is provided by casein glycomacropeptide.

22. The method according to claim 21, wherein the formula comprises a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by casein glycomacropeptide.

23. The method according to claim 1, wherein the casein glycomacropeptide comprises a casein glycomacropeptide having an enhanced concentration of sialic acid.

24. The method according to claim 23, wherein the casein glycomacropeptide having an enhanced concentration of sialic acid comprises high-sialic acid casein glycomacropeptide with reduced threonine.

25. The method according to claim 24, wherein the casein glycomacropeptide is included in a formula having a total protein content of between 13 and 15 grams/liter of which no more than 30% by weight is provided by a casein glycomacropeptide having an enhanced concentration of sialic acid and having a threonine content of not over 10 grams/16 grams nitrogen.

26. The method according to claim 1, wherein the casein glycomacropeptide is included in a formula having a total protein content of about 14 grams/liter of which not over 4% by weight is threonine and having a sialic acid content of at least 400 mg/liter.

27. The method according to claim 1, further comprising measuring the learning and/or the memory behavior of the mammal following the administration of the casein glycomacropeptide.

28. A method of increasing brain protein-bound sialic acid in a mammal, the method comprising administering to the mammal an amount of casein glycomacropeptide that is sufficient to increase the brain protein-bound sialic acid in the mammal.

29. The method according to claim 28, wherein the brain protein-bound sialic acid is increased by an amount of at least about 5%.

30. A method of improving learning and/or memory behavior in a mammal, the method comprising:

determining whether the mammal is one that is in need of improvement in learning and/or memory; and

, if so

administering to the mammal casein glycomacropeptide in an amount sufficient to improve learning and/or memory behavior in the mammal.