Methods and compositions for encapsulation of cells
First Claim
1. A method of altering development of a neuron comprising contacting said neuron with a composition comprising a peptide amphiphile.
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Accused Products
Abstract
The present invention relates to methods and compositions for altering (e.g., augmenting or stimulating) differentiation and growth of cells (e.g., neural progenitor cells and neurons). In particular, the present invention relates to compositions comprising one or more self-assembling peptide amphiphiles (e.g., in solution or that generate (e.g., self-assemble into) nanofibers (e.g., that are able to encapsulate cells and promote cellular differentiation (e.g., neurite development))) and methods of using the same. Compositions and methods of the present invention find use in research, clinical (e.g., therapeutic) and diagnostic settings.
105 Citations
20 Claims
- 1. A method of altering development of a neuron comprising contacting said neuron with a composition comprising a peptide amphiphile.
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7. A method for treating a subject comprising:
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a) providing a subject with a damaged nerve, and b) administering a composition comprising a peptide amphiphile to said subject under conditions such that neuron growth occurs in said subject. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A pharmaceutical composition comprising a peptide amphiphile comprising an IKVAV (SEQ ID NO:
- 1) sequence, wherein said composition is configured to alter neuron growth in a subject.
- View Dependent Claims (19, 20)
Specification