Method and system for assessment of biomarkers by measurement of response to surgical implant
First Claim
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1. A method for assessing at least one biomarker in a region of interest of a patient and a response of the at least one biomarker to a surgical implant, the method comprising:
- (a) obtaining at least one pre-implantation 3D image data set in the region of interest before the surgical implant is implanted into the region of interest;
(b) implanting the surgical implant into the region of interest (c) obtaining at least one post-implantation 3D image data set in the region of interest after the surgical implant has been implanted; and
(d) extracting biomarker measurements from the at least one pre-implantation 3D image data set and the at least one post-implantation 3D image data set.
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Abstract
In a human or animal organ or other region of interest, specific objects, such as liver metastases and brain lesions, serve as indicators, or biomarkers, of disease. In a three-dimensional image of the organ, the biomarkers are identified and quantified both before and after a surgical implant is implanted, and their reaction to the surgical implant is observed. Statistical segmentation techniques are used to identify the biomarker in a first image and to carry the identification over to the remaining images.
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17 Claims
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1. A method for assessing at least one biomarker in a region of interest of a patient and a response of the at least one biomarker to a surgical implant, the method comprising:
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(a) obtaining at least one pre-implantation 3D image data set in the region of interest before the surgical implant is implanted into the region of interest;
(b) implanting the surgical implant into the region of interest (c) obtaining at least one post-implantation 3D image data set in the region of interest after the surgical implant has been implanted; and
(d) extracting biomarker measurements from the at least one pre-implantation 3D image data set and the at least one post-implantation 3D image data set. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification