Method and arrangement for the tiration of physiological measuring signals in conjunction with the observation of a patient in terms of sleep-related respiratory problems

• US 20060249149A1
• Filed: 03/17/2004
• Published: 11/09/2006
• Est. Priority Date: 03/17/2003
• Status: Abandoned Application

• Current Assignee: MAP Medizin-Technologie GMBH (ResMed Incorporated)
• Original Assignee: MAP Medizin-Technologie GMBH (ResMed Incorporated)
• Inventors: Meier, Jörg, Stauffenberg, Caspar Graf, Madaus, Stefan, Heidmann, Dieter, Klaus, Dieter, Schätzl, Stefan
• Application Number:
  US10/549,650
• Publication Number:
  US 20060249149A1
• Time in Patent Office: Days
• US Class Current: 128/204.180
• CPC Class Codes: A61B 5/087 Measuring breath flow
• CPC Class Codes: A61B 5/7232 involving compression of the physiological signal, e.g. to extend the signal recording period
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/024 including calculation means, e.g. using a processor
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit

Abstract

The invention concerns a method and an arrangement for the titration of physiological measurement signals. In particular the invention concerns a method and an arrangement for detection and evaluation of a measurement signal indicative in respect of the respiratory gas flow of a sleeping person, in conjunction with the observation of sleep-related breathing disorders. The object of the invention is that of providing solutions which make it possible to detect physiological properties which are relevant in respect of respiration during a sleeping phase, in a manner which makes it possible to assess the physiological state of the person being investigated with a high level of reliability and correctly match any therapy boundary conditions that are required. In accordance with a first aspect of the present invention that object is attained by a method of providing an evaluation result indicative in respect of the physiological state on the basis of measurement signals which are related to the respiration of a person, wherein evaluation features are generated from said measurement signals using a plurality of evaluation systems, and in the framework of a result-generation step based thereon at least one evaluation result is generated, by the evaluation features being subjected to interlinking consideration, wherein the measurement signals are detected in titration sequences which are different in respect of the respiratory gas pressure level applied to the patient and the generation of at least a part of the evaluation features or the evaluation result is effected having regard to the respective titration sequence pressure.

Claims

1. A method of generating an evaluation result which is specific in respect of the physiological state of a person, on the basis of measurement signals which are in a relationship with the respiration of the person, wherein evaluation features are generated from said measurement signals, using a plurality of evaluation systems, and at least one evaluation result is generated in the context of a result-generation step based thereon, by the evaluation features being subjected to interlinking consideration, and the measurement signals are detected in titration sequences which are different in respect of the respiratory gas pressure level applied to the patient and the generation of at least a part of the evaluation features or the evaluation result is effected having regard to the respective titration sequence pressure.

2. A method as set forth in claim 1 characterised in that the titration sequence pressure is substantially constant within a titration sequence.

3. A method as set forth in claim 1 characterised in that the titration sequence pressure follows a pressure control concept within a titration sequence.

4. A method as set forth in claim 1 characterised in that the length in respect of time of the titration sequence is determined by sequence length criteria.

5. A method as set forth in claim 4 characterised in that the sequence length criteria include criteria of a minimum time duration.

6. A method as set forth in claim 4 characterised in that the sequence length criteria include criteria in respect of a minimum respiration number.

7. A method as set forth in claim 4 characterised in that the sequence length criteria include obstruction indicators.

8. A method as set forth in claim 4 characterised in that the sequence length criteria include a forward-switching criterion.

9. A method as set forth in claim 1 characterised in that the pressure control within a titration sequence is matched to the detection of given indicators, wherein included therein are indicators for central breathing disorders and/or obstructive breathing disorders and/or patient-specific breathing patterns.

10. A method as set forth in claim 9 characterised in that apnoea indicators are among the indicators.

11. A method as set forth in claim 9 characterised in that hypopnoea indicators are among the indicators.

12. A method as set forth in claim 9 characterised in that flow limitation indicators are among the indicators.

13. A method as set forth in claim 1 characterised in that actuation of the titration sequences is effected in accordance with a sequence control concept.

14. A method as set forth in claim 13 characterised in that the sequence control concept includes at least one period of successively rising pressure stages or that the sequence control concept includes at least one period of successively falling pressure stages.

15. A method as set forth in claim 13 characterised in that the sequence control concept provides a plurality of titration sequences with different titration sequence pressures, wherein in the context of actuation of said titration sequence pressures intermediate phase pressures are actuated, in which the respiratory gas pressure level is at a level which is higher than the titration sequence pressure of a preceding titration sequence and a subsequent titration sequence.

16. A method as set forth in claim 15 characterised in that the intermediate phase pressures are each at the same respective pressure level.

17. A method as set forth in claim 15 characterised in that the intermediate phase pressures are at an expected suitable therapy pressure.

18. A method as set forth in claim 13 characterised in that the sequence control concept extends over a titration period and a validation period follows the titration period.

19. A method as set forth in claim 18 characterised in that adaptation or plausibility checking of the evaluation results is effected during a validation period.

20. A method as set forth in claim 18 characterised in that in the context of the validation period suitably testing of a patient-specific pressure control configuration is effected.

21. A method as set forth in claim 1 characterised in that a feature contribution which is predominantly contained in the evaluation features is generated within a generation time window which is smaller than an interlinking time window provided for the interlinking consideration.

22. A method as set forth in claim 1 characterised in that physiological typification of the patient in relation to obstructive, central and/or hybrid breathing disorders is effected on the basis of the interlinking consideration.

23. A method as set forth in claim 1 characterised in that a configuration data network is generated on the basis of the interlinking consideration, for the configuration of the respiratory gas pressure regulation of a respiratory gas feed device.

24. A method as set forth in claim 1 characterised in that the evaluation features are generated on the basis of breath stability criteria.

25. A method as set forth in claim 1 characterised in that the evaluation features are generated on the basis of statistical evaluation procedures.

26. A method as set forth in claim 1 characterised in that the evaluation features are generated as a feature field.

27. A method as set forth in claim 1 characterised in that normal respiration phase lengths and/or normal respiration-characteristic features and/or features for regular or irregular respiration phase lengths and/or regular and/or irregular features, characteristic evaluation features, are generated as the evaluation feature.

28. A method as set forth in claim 1 characterised in that flow limitation phase lengths and/or flow limitation-characteristic features or data sets and/or features for obstructive breathing disorders and/or obstruction-characteristic features are generated as the evaluation features.

29. A method as set forth in claim 1 characterised in that apnoea-characteristic features or data sets are generated as evaluation features.

30. A method as set forth in claim 1 characterised in that snoring phase lengths and/or snoring phase-characteristic features are generated as evaluation features.

31. A method as set forth in claim 1 characterised in that features which are indicative in respect of the occurrence of central and/or hybrid breathing disorders or in respect of the ratio of the proportion or the duration of central to hybrid or central to obstructive breathing disorders are generated as evaluation features.

32. A method as set forth in claim 1 characterised in that features for Cheyne-Stokes phase lengths or Cheyne-Stokes characteristic features or data sets are generated as evaluation features.

33. A method as set forth in claim 1 characterised in that features in respect of periodic processes, for example the phase length of periodic processes, are generated as evaluation features.

34. A method as set forth in claim 1 characterised in that features for the hypoventilation phase lengths or hyperventilation-characteristic features or data sets are generated as evaluation features.

35. A method as set forth in claim 1 characterised in that features in respect of breath-specific times, for example features in respect of the inspiration time, the expiration time and the overall cycle, are ascertained as evaluation features.

36. A method as set forth claim 1 characterised in that features in respect of the maximum respiration volume flow of inspiration and expiration are generated as evaluation features.

37. A method as set forth in claim 1 characterised in that mouth breathing-indicative features of inspiration and/or expiration are ascertained as evaluation features.

38. A method as set forth in claim 1 characterised in that lung draw volume-indicative features or data sets are generated as evaluation features.

39. A method as set forth in claim 1 characterised in that body position-indicative features or data sets are generated as evaluation features.

40. A method as set forth in claim 1 characterised in that sleep phase-characteristic features or data sets are generated as the evaluation feature.

41. A method as set forth in claim 1 characterised in that titration-characteristic features, for example titration mode phases, or data sets or titration measurement values are used as the evaluation feature.

42. A method as set forth in claim 1 characterised in that special intervals of the titration sequences or data sets are generated or recorded as the evaluation feature.

43. A method as set forth in claim 1 characterised in that features in respect of the proportion or degree of leakage are generated as the evaluation feature.

44. A method as set forth in claim 1 characterised in that leakage times are stored as the evaluation feature.

45. A method as set forth in claim 1 characterised in that the titration differential pressure is stored as the evaluation feature.

46. A method as set forth in claim 1 characterised in that the initial and/or end titration pressure is ascertained and/or recorded as the evaluation feature.

47. A method as set forth in claim 1 characterised in that the titration pressure pattern is recorded as the evaluation feature.

48. A method as set forth in claim 1 characterised in that an inspiration volume flow/pressure diagram in dependence on detected breathing disorders is generated as the evaluation feature.

49. A method as set forth in claim 1 characterised in that generated evaluation features are stored with association in respect of their position in respect of time in the measurement signal acquisition period.

50. A method as set forth in claim 1 characterised in that a flow limitation index is generated in the context of the interlinking consideration.

51. A method as set forth in claim 1 characterised in that an apnoea/hypopnoea index is generated in the context of the interlinking consideration.

52. A method as set forth in claim 1 characterised in that a snoring index is generated in the context of the interlinking consideration.

53. A method as set forth in claim 1 characterised in that a mouth breathing/nasal breathing index is generated in the context of the interlinking consideration.

54. A method as set forth in claim 1 characterised in that a sleep time index is generated in the context of the interlinking consideration.

55. A method as set forth in claim 1 characterised in that a sleep phase index is generated in the context of the interlinking consideration.

56. A method as set forth in claim 1 characterised in that a periodic respiration index is generated in the context of the interlinking consideration.

57. A method as set forth in claim 1 characterised in that a respiration volume index is generated in the context of the interlinking consideration.

58. A method as set forth in claim 1 characterised in that in the context of the interlinking consideration the evaluation features are taken into consideration with a weighting which is determined for the respective interlinking.

59. A method as set forth in claim 1 characterised in that the evaluation features are generated on the basis of a v-measurement.

60. A method as set forth in claim 1 characterised in that at least a part of the evaluation features is generated having regard to the first and/or the second derivative of the configuration in respect of time of the respiratory gas flow.

61. A method as set forth in claim 1 characterised in that in the context of detecting the v-signal the pressure of the respiratory gas which flows to the patient corresponds to the ambient pressure.

62. A method as set forth in claim 1 characterised in that in the context of detecting the v-signal the respiration gas pressure is set to a pressure level which differs from the ambient pressure.

63. Apparatus for generating an evaluation result which is specific in respect of the physiological state of a breathing person, on the basis of measurement signals which are related to the respiration of the person, comprising a measurement signal input device and a computing device for providing a plurality of evaluation systems, wherein the computing device is configured in such a way that it generates evaluation features from said measurement signals by the evaluation systems and said evaluation features are subjected in the context of a result-generation step based thereon to interlinking consideration and an output signal or an output data set which contains the evaluation result is generated on the basis of the interlinking consideration, and the measurement signals are detected in titration sequences which are different in respect of the respiratory gas pressure level applied to the patient and the generation of at least a part of the evaluation features or the evaluation result is effected having regard to the respective titration sequence pressure.

64. A method of patient-specific configuration of a CPAP-apparatus in which in the context of a titration period in respect of the physiological state of a person specific evaluation results are obtained on the basis of measurement signals which are in a relationship with the respiration of the person, wherein evaluation features are generated from said measurement signals, using a plurality of evaluation procedures, and said patient-specific setting of the CPAP-apparatus is effected in dependence on said evaluation features, and following the titration period operation of the CPAP-apparatus is effected under therapy conditions which are ascertained as suitable, wherein in the context of the titration mode control of the respiratory gas pressure is effected in accordance with a pressure regulating concept which under program control causes the setting of different respiration gas pressure levels in such a way that the measurement signals are detected in titration sequences which are different in respect of the respiratory gas pressure level applied to the patient, wherein the generation of at least a part of the evaluation features is effected having regard to the respective titration sequence pressure.

65. A method as set forth in claim 64 characterised in that the titration period extends over the first 30% of the sleep period of the patient.

66. A method as set forth in claim 65 characterised in that the titration period and the subsequent validation period are executed in the course of a stay on the part of the patient in a sleep laboratory.

67. A method as set forth in claim 64 characterised in that the titration period is implemented using the CPAP-apparatus provided for the therapy.

68. A method as set forth in claim 67 characterised in that the therapy apparatus can be coupled to a control unit which at least during the titration period causes operation of the apparatus in accordance with a pressure control concept for actuating a plurality of titration sequence pressure levels.

69. A method as set forth in claim 64 characterised in that a patient-specific effective therapy pressure is ascertained by the titration method.

70. A method as set forth in claim 64 characterised in that assessment bases for a prognosis of breathing-related illnesses are afforded by the titration method.

71. A method as set forth in claim 64 characterised in that evaluation results are generated by the titration method, which results permit classification or assessment of a patient in respect of obstructive, central and/or hybrid breathing disorders or the provision of a therapy recommendation.

72. A method as set forth in claim 64 characterised in that a standardised and protocolled diagnostic procedure is operated by the titration method.

73. A method as set forth in claim 64 characterised in that the evaluation features are convertible into various medical defined standard assessments.

74. A method as set forth in claim 64 characterised in that assessment bases are generated (prior to the actual illness) diagnosed or prognosticated.