Delivery of analgesics through an inhalation route
First Claim
1. A composition for delivery of acetaminophen consisting of a condensation aerosol a) formed by volatilizing a thin layer of acetaminophen on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of acetaminophen and condensing the heated vapor of acetaminophen to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% acetaminophen degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
0 Assignments
0 Petitions
Accused Products
Abstract
The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a method aspect of the present invention, an analgesic is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of acetaminophen, orphenadrine or tramadol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% acetaminophen, orphenadrine or tramadol degradation products. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation is provided which comprises: a) a thin coating of an acetaminophen, orphenadrine or tramadol composition and b) a device for dispensing said thin coating as a condensation aerosol.
-
Citations
18 Claims
-
1. A composition for delivery of acetaminophen consisting of a condensation aerosol
a) formed by volatilizing a thin layer of acetaminophen on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of acetaminophen and condensing the heated vapor of acetaminophen to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% acetaminophen degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
-
4. A composition for delivery of orphenadrine consisting of a condensation aerosol
a) formed by volatilizing a thin layer of orphenadrine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of orphenadrine and condensing the heated vapor of orphenadrine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% orphenadrine degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
-
7. A composition for delivery of tramadol consisting of a condensation aerosol
a) formed by volatilizing a thin layer of tramadol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to produce a heated vapor of tramadol and condensing the heated vapor of tramadol to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% tramadol degradation products, and c) the condensation aerosol has an MMAD of less than 3 microns.
-
10. A method of producing acetaminophen in an aerosol form comprising:
-
a. heating a thin layer of acetaminophen on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the acetaminophen to form a heated vapor of the acetaminophen, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the acetaminophen comprising less than 5% acetaminophen degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (11, 12)
-
-
13. A method of producing orphenadrine in an aerosol form comprising:
-
a. heating a thin layer of orphenadrine on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the orphenadrine to form a heated vapor of the orphenadrine, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the orphenadrine comprising less than 5% orphenadrine degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (14, 15)
-
-
16. A method of producing tramadol in an aerosol form comprising:
-
a. heating a thin layer of tramadol on a solid support, having the surface texture of a metal foil, to a temperature sufficient to volatilize the tramadol to form a heated vapor of the tramadol, and b. during said heating, passing air through the heated vapor to produce aerosol particles of the tramadol comprising less than 5% tramadol degradation products, and an aerosol having an MMAD of less than 3 microns. - View Dependent Claims (17, 18)
-
Specification