Cytoprotection through the use of hif hydroxylase inhibitors
First Claim
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1. A method for conferring cytoprotection on a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby conferring cytoprotection on the cell.
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Abstract
The invention relates to methods for conferring cytoprotection, or for inducing a cytoprotective effect, by administering a compound that inhibits HIF hydroxylase. Compounds for use in these methods are also provided.
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Citations
30 Claims
- 1. A method for conferring cytoprotection on a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby conferring cytoprotection on the cell.
- 2. A method for inducing a cytoprotective effect in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby inducing the cytoprotective effect in the cell.
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10. A method for increasing adrenomedullin expression in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby increasing adrenomedullin expression in the cell.
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11. A method for increasing HSP70 expression in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby increasing HSP70 expression in the cell.
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12. A method for increasing heme oxygenase-1 expression in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby increasing heme oxygenase-1 expression in the cell.
- 13. A method for decreasing caspase expression in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby decreasing caspase expression in the cell.
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15. A method for preserving ATP levels in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby preserving ATP levels in the cell.
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16. A method for reducing or preventing apoptosis in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby reducing or preventing apoptosis in the cell.
- 17. A method for increasing expression of an anti-apoptotic factor in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby increasing expression of the anti-apoptotic factor in the cell.
- 19. A method for increasing expression of a factor having anti-oxidant activity in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby increasing expression of the factor having anti-oxidant activity in the cell.
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21. A method for reducing or preventing oxidative damage in a cell, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby reducing or preventing oxidative damage in the cell.
- 22. A method for conferring cytoprotection to a cell exposed to or at risk for exposure to stress, the method comprising administering to the cell an effective amount of a compound that inhibits HIF hydroxylase activity, thereby conferring cytoprotection to the cell.
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