Stable ophthalmic oil-in-water emulsions with Omega-3 fatty acids for alleviating dry eye
First Claim
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1. An ophthalmic composition comprising:
- oil globules dispersed in an aqueous phase, said globules comprising;
(a) a surfactant component;
(b) a polar oil component comprising an Omega-3 fatty acid, wherein the surfactant to oil ratio is adjusted such that said oil globules have an average size of about 0.1 micron or less; and
(c) a viscosity modifying agent in a concentration that produces a viscosity at least as viscous as 0.25% 800K (w/w) Sodium Hyaluronate.
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Abstract
An ophthalmic composition includes oil globules dispersed in an aqueous phase. The globules include a surfactant component, a polar oil component that includes an Omega-3 fatty acid and a viscosity modifying agent. The surfactant to oil ratio produces an average size of globules of about 0.1 microns or less. The viscosity is at least as viscous as 0.25% 800K sodium hyaluronate. The composition can be used for treatment of dry eye. The compositions are stable and can have anti-microbial activity sufficient for use as contact lens disinfecting solutions.
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Citations
43 Claims
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1. An ophthalmic composition comprising:
oil globules dispersed in an aqueous phase, said globules comprising;
(a) a surfactant component;
(b) a polar oil component comprising an Omega-3 fatty acid, wherein the surfactant to oil ratio is adjusted such that said oil globules have an average size of about 0.1 micron or less; and
(c) a viscosity modifying agent in a concentration that produces a viscosity at least as viscous as 0.25% 800K (w/w) Sodium Hyaluronate. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. An ophthalmic composition comprising:
oil globules dispersed in an aqueous phase, said globules comprising;
(a) a surfactant component;
(b) a polar oil component comprising an Omega-3 fatty acid; and
(c) a polymeric quaternary amine preservative in an amount sufficient to produce a composition that meets U.S. preservative efficacy testing standards. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43)
Specification