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Formulations and methods for treating amyloidosis

  • US 20060252829A1
  • Filed: 04/17/2006
  • Published: 11/09/2006
  • Est. Priority Date: 04/15/2005
  • Status: Active Grant
First Claim
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1. A method of treating or preventing AA amyloidosis in a target subject comprising, administering to the target subject a therapeutically effective amount of a compound having the formula:


  • Y—

    (CH2)n

    [CH2Y]m



    (I) wherein Y is SO3X or OSO3X independently chosen for each occurrence;

    X is cationic group independently chosen for each occurrence;

    n is 1, 2, 3 or 4; and

    m is 1 or 2, such that AA amyloidosis is treated or prevented while maintaining an acceptable tolerance index (ATI) for a parameter associated with renal impairment (PRI), wherein the target subject is being treated for AA amyloidosis and has or is susceptible to a parameter associated with renal impairment.

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