Method of treating skin disorders with stratum corneum piercing device

• US 20060253078A1
• Filed: 04/25/2005
• Published: 11/09/2006
• Est. Priority Date: 04/25/2005
• Status: Abandoned Application

• Current Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Consumer Companies Incorporated (Johnson & Johnson)
• Inventors: Sun, Ying, McDonough, Justin, Wu, Jeffrey M., Liu, Jue-Chen, Maghribi, Mariam, Lambino, Danilo
• Application Number:
  US11/113,890
• Publication Number:
  US 20060253078A1
• Time in Patent Office: Days
• US Class Current: 604/173
• CPC Class Codes: A61B 2017/00765 Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
• CPC Class Codes: A61M 2037/0023 Drug applicators using microneedles
• CPC Class Codes: A61M 2037/0046 Solid microneedles
• CPC Class Codes: A61M 37/00 Other apparatus for introducing media into the body for reproduction or fertilisation A61B17/425; apparatus for iontophoresis or cataphoresis A61N1/30; Percutany, i.e. introducing medicines into the body by diffusion through the skin salt baths A61H33/04
• CPC Class Codes: A61M 37/0015 by using microneedles
• CPC Class Codes: A61N 1/306 Arrangements where at least part of the apparatus is introduced into the body
• CPC Class Codes: A61N 1/325 for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body electrodes for external use A61N1/0428
• CPC Class Codes: A61P 17/10 Anti-acne agents

Abstract

The present invention features a device having a barrier membrane contacting surface, the device containing: a power source; a first conductive electrode; a second conductive electrode; and a reservoir; wherein said power source is in electric communication with said first conductive electrode and said second conductive electrode, wherein said first conductive electrode and said second conductive electrode are arranged such that they are both capable of being in ionic communication with a carrier upon the inclusion of said carrier to said reservoir; and the use thereof.

Claims

1. A method of treating a skin disorder with a device, said device comprising (i) a microprotrusion member having a skin-contacting surface and plurality of stratum corneum-piercing microprotrusions thereon and (ii) a composition for treatment of said skin disorder, wherein said method comprises piercing the stratum corneum of said skin with said microprotrusion member and applying said composition from said device to said skin.

2. A method of claim 1, wherein said composition is applied to said skin after piercing the stratum corneum of said skin with said microprotrusion member.

3. A method of claim 1, wherein said composition is coated on (i) at least a portion of said skin-contacting surface, (ii) at least a portion of one or more of said stratum-corneum piercing microprotrusions, or (iii) at least a portion of said skin-contacting surface and at least a portion of one or more of said stratum-corneum piercing microprotrusions.

4. A method of claim 1, wherein said device comprises a reservoir containing said composition, wherein said skin-contacting surface has at least one opening, and said reservoir is in communication with said at least one opening such that said composition can move from said reservoir, through said at least one opening, and onto said skin.

5. A method of claim 1, wherein said device comprises a reservoir containing said composition, wherein at least one of said microprotrusions is hollow, and said reservoir is in communication with said at least one hollow microprotrusion such that said composition can move from said reservoir and through said at least one hollow microprotrusion.

6. A method of claim 5, wherein said composition moves through said at least one hollow microprotrusion while said at least one hollow microprotrusion is in said skin.

7. A method of claim 1, wherein said device comprises from about 5 to about 100 microprotrusions having a length of from about 100 to about 500 microns.

8. A method of claim 4, wherein said device comprises from about 5 to about 100 microprotrusions having a length of from about 100 to about 500 microns.

9. A method of claim 1, wherein device rotates said microprotrusion member upon contact with said skin.

10. A method of claim 4, wherein said device rotates said microprotrusion member upon contact with said skin.

11. A method of claim 8, wherein said device rotates said microprotrusion member upon contact with said skin.

12. A method of claim 1, wherein said device is affixed to said skin.

13. A method of claim 4, wherein said device is affixed to said skin.

14. A method of claim 8, wherein said device is affixed to said skin.

15. A method of claim 1, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, discoloration, pain, itch, and a scar.

16. A method of claim 4, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

17. A method of claim 7, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

18. A method of claim 8, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

19. A method of claim 9, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

20. A method of claim 10, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

21. A method of claim 11, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

22. A method of claim 12, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

23. A method of claim 13, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.

24. A method of claim 14, wherein the skin disorder is selected from the group consisting of wrinkles, lack of firmness, lack of elasticity, hyperpigmentation, and a scar.