Integrated biosensor and simulation system for diagnosis and therapy
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Abstract
BioMEMS/NEMS appliance biologically monitors an individual, using biosensors to detect cellular components. Data is simulated or analyzed using systems-biology software, which provides diagnostic or therapeutic guidance.
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Citations
48 Claims
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1-20. -20. (canceled)
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21. A system for detecting a genetic predisposition of a patient for metabolizing a drug comprising:
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a microarray comprising one or more oligonucleotide probes for detecting by hybridization a presence of one or more DNA polymorphisms of CYP2D6 labeled with a fluorescent dye;
a laser scanner for detecting a hybridization pattern produced on the microarray labeled by the fluorescent dye; and
a data analysis module for determining a phenotype of a patient, such that a dosage of one or more drugs comprising β
-adrenergic receptor antagonists, neuroleptics, or tricyclic antidepressants is personalizable according to the patient phenotype. - View Dependent Claims (23, 24)
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22. A method for detecting a genetic predisposition of a patient for metabolizing a drug comprising the steps of:
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hybridizing DNA acquired from a patient and labeled with a fluorescent dye to a microarray comprising one or more oligonucleotide probes for detecting a presence of one or more DNA polymorphisms of CYP2D6;
scanning the microarray with a laser for detecting a hybridization pattern produced on the microarray by sensing the fluorescent dye; and
determining a phenotype of the patient using a data analysis module such that a dosage of one or more drugs comprising β
-adrenergic receptor antagonists, neuroleptics, or tricyclic antidepressants is personalizable according to the patient phenotype.
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25. A method for diagnosing an infectious disease or infection comprising the steps of:
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hybridizing biotinylated biological samples acquired from a patient to a site on a microarray comprising biotinylated reporter probes bound to a streptavidin gel;
scanning the microarray with a laser for detecting one or more fluorescence ratios by sensing the fluorescent dye; and
reporting the presence or absence of one or more nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable. - View Dependent Claims (26, 27, 29, 30)
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28. An apparatus for diagnosing an infectious disease or infection comprising:
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microarray comprising biotinylated reporter probes bound to a streptavidin gel for hybridizing biotinylated biological samples acquired from a patient;
a laser scanner for scanning the microarray to detect one or more fluorescence ratios by sensing the hybridized biotinylated biological samples; and
a user interface for reporting the presence or absence of one or more nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable.
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31. An apparatus for diagnosing an infectious disease or infection comprising:
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a microarray for hybridizing biotinylated biological samples acquired from a patient to a site comprising biotinylated reporter probes bound to a streptavidin gel;
an automated platform for scanning the microarray with a laser for detecting fluorescence ratios by sensing the fluorescent dye; and
a user interface for reporting the presence or absence of nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable. - View Dependent Claims (32)
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33. A method for diagnosing an infectious disease or infection comprising the steps of:
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hybridizing biotinylated biological samples acquired from a patient to a microarray site comprising biotinylated reporter probes bound to a streptavidin gel;
scanning the microarray with a laser for detecting fluorescence ratios by sensing the fluorescent dye; and
reporting the presence or absence of nucleic acid sequences for specific organisms or genetic mutations associated with disease such that an infection comprising influenza, herpes, chlamydia, pneumonia, or cytomegalic inclusion disease is diagnosable on a user interface. - View Dependent Claims (34)
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35. A method for diagnosing a patient or making therapy recommendations comprising the steps of:
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storing information in a database such that patient records comprising reports indicating gene expression, a history of diagnoses, patient age, height, weight, symptoms, allergies, diet, previous or present medications, medical or family history of disease, sickness or infection, results of previous blood or urine tests, or environmental or immunological factors is accessible using an on-screen search of a patient record;
using mathematical methods comprising neural networks, artificial intelligence, fuzzy systems, or probabilities on the patient records to simulate one or more conditions of a patient; and
reporting one or more diagnoses or therapy recommendations based on the conditions of the patient to a medical professional on a user interface. - View Dependent Claims (36, 37, 38)
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39. An apparatus for diagnosing a patient or making therapy recommendations comprising:
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a database for storing patient records such that reports comprising gene expression analysis, a history of diagnoses, patient age, height, weight, symptoms, allergies, diet, previous or present medications, medical or family history of disease, sickness or infection, results of previous blood or urine tests, or environmental or immunological factors is accessible using an on-screen search of a patient record;
a data analyzer using mathematical methods comprising neural networks, artificial intelligence, fuzzy systems, or probabilities on the patient records to simulate one or more conditions of a patient; and
a user interface for reporting one or more diagnoses or therapy recommendations based on the conditions of the patient to a medical professional on a user interface. - View Dependent Claims (40, 41, 42)
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43. A method for treating a patient with HIV comprising the steps of:
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using an HIV diagnostic system to diagnose a patient as HIV positive;
storing the HIV positive diagnosis in a database such that patient records comprising reports indicating gene expression, a history of diagnoses, patient age, height, weight, symptoms, allergies, diet, previous or present medications, medical or family history of disease, sickness or infection, results of previous blood or urine tests, or environmental or immunological factors is accessible using an on-screen search of a patient record; and
using mathematical methods comprising neural networks, artificial intelligence, fuzzy systems, or probabilities on the patient records to simulate one or more conditions of a patient; and
reporting one or more therapy recommendations based on the conditions of the patient to a medical professional on a user interface.
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44. An apparatus for treating a patient with HIV comprising:
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an HIV diagnostic system to diagnose a patient as HIV positive;
a database for storing the HIV positive diagnosis such that patient records comprising reports indicating gene expression, a history of diagnoses, patient age, height, weight, symptoms, allergies, diet, previous or present medications, medical or family history of disease, sickness or infection, results of previous blood or urine tests, or environmental or immunological factors is accessible using an on-screen search of a patient record;
a data analyzer using mathematical methods comprising neural networks, artificial intelligence, fuzzy systems, or probabilities on the patient records to simulate one or more conditions of a patient; and
a user interface for reporting one or more therapy recommendations based on the conditions of the patient to a medical professional on a user interface.
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45. An apparatus for analyzing a patient'"'"'s metabolic profile comprising:
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a sensor comprising microfluidics to mix reagents and a biological sample from a patient to chemically react;
a processor for monitoring chemical reactions by optical communication such that the concentrations of ions comprising H+, Ca2+, K+, Na+, Mg2+, Zn2+, Cl−
, NO2−
, O2, NO or glucose molecoles are determined such that metabolic conditions are diagnosable; and
a user interface connected to a network for accessing the concentrations of ions from a database coupled to the processor.
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46. A method for analyzing a patient'"'"'s metabolic profile comprising the steps of:
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mixing reagents and a biological sample from a patient to chemically react using microfluidics;
monitoring chemical reactions by optical communication such that concentrations of one or more ions comprising H+, Ca2+, K+, Na+, Mg2+, Zn2+, Cl−
, NO2−
, O2, NO or glucose molecules are determined such that metabolic conditions are diagnosable; and
accessing the concentrations from a database coupled to the processor over a network using a user interface.
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47. A method for diagnosing immunity diseases comprising the steps of:
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sensing levels of HLA (human leukocyte antigen) complex by amplifying and sequencing a patient'"'"'s genomic DNA;
generating a report accessible via a user interface wherein the report is customizable by the user such that a diagnosis is determinable.
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48. An apparatus for diagnosing hormonal changes, cancer, infectious diseases or diabetes comprising:
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a chip-based ELISA platform for binding a target antigene obtained from a patient to an adsorbed antibody;
an electrochemical detector using current to detect a concentration of the target antigens; and
a user interface for generating a report such that one or more diagnoses or therapy recommendations can be made based on the conditions of the patient to a medical professional.
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Specification