Multiple local probe measuring device and method

• US 20060255818A1
• Filed: 07/17/2006
• Published: 11/16/2006
• Est. Priority Date: 09/20/1999
• Status: Active Grant

• Current Assignee: European Molecular Biology Laboratory
• Original Assignee: European Molecular Biology Laboratory
• Inventors: Altmann, Stephan Maxmilian, Horber, Johann Karl Heinrich
• Granted Patent: US 7,312,619 B2
• Time in Patent Office: Days
• US Class Current: 850/1
• CPC Class Codes: G01Q 20/02 by optical means
• CPC Class Codes: G01Q 40/00 Calibration, e.g. of probes
• CPC Class Codes: G01Q 70/06 Probe tip arrays
• CPC Class Codes: Y10S 977/863 Atomic force probe
• CPC Class Codes: Y10S 977/869 Optical microscope
• CPC Class Codes: Y10S 977/874 Probe tip array
• CPC Class Codes: Y10S 977/875 with tip detail

Abstract

The invention provides a local probe measuring device for effecting local measurements referring to a sample, comprising a first local probe for local measurements with respect to a sample or a reference surface, a second local probe for local measurements with respect to the sample or the reference surface, a measurement condition adjustment arrangement adapted to commonly adjust a first measurement condition of the first local probe with respect to the sample or the reference surface and a second measurement condition of the second local probe with respect to the sample or the reference surface, a detection arrangement comprising a first detection arrangement associated with the first local probe adapted to independently detect first measurement data referring to local measurements reflected by said first local probe and a second detection arrangement associated with the second local probe adapted to independently detect second measurement data referring to local measurements effected by said second local probe. Further, methods for effecting local measurements and local manipulations by means for multiple local probes are provided.

Claims

1. A local probe measuring device for effecting local measurements referring to a:

sample, comprising;

a first local probe for local measurements with respect to a sample or a reference surface,

a second local probe for local measurements with respect to the sample or the reference surface,

a rigid mechanical coupling between the first local probe and the second local probe,

a positioning arrangement adapted to commonly adjust distance relations of the probes with respect to the sample or the reference surface to commonly adjust

a first measurement condition of the first local probe with respect to the sample or the reference surface and p2 a second measurement condition of the second local probe with respect to the sample or the reference surface,

a detection arrangement comprising

a first detection arrangement associated with the first local probe adapted to independently detect first measurement data refering to local measurements effected by said first local probe and

a second detection arrangement associated with the second local probe adapted to independently detect second measurement data refering to local measurements effected by said second local probe,

wherein at least one of said local probes has associated an interaction field generator generating an interaction field to bring about or to influence an local interaction of the respective local probe with the sample or the reference surface.

2. The device according to claim 1, characterized in that said interaction field is an electromagnetic or optical field interacting with the sample or the reference surface.

3. The device according to claim 1, characterized by said local interaction of the respective local probe with said sample or said reference surface being a detection of a response of the sample or the reference surface to the interaction field.

4. The device according to claim 1, characterized by said detection of said response comprising a detection of an optical near-field resulting from an illumination of said sample or reference surface by an optical field serving as said interaction field, the respective local probe having associated an aperture to serve as near-field optical microscopy probe.

5. A local probe measuring device for effecting local measurements referring to a sample, comprising:

a first local probe for local measurements with respect to a sample or a reference surface,

a second local probe for local measurements with respect to the sample or the reference surface,

a rigid mechanical coupling between the first local probe and the second local probe,

a positioning arrangement adapted to commonly adjust distance relations of the probes with respect to the sample or the reference surface to commonly adjust

a first measurement condition of the first local probe with respect to the sample or the reference surface and

a second measurement condition of the second local probe with respect to the sample or the reference surface,

a detection arrangement comprising

a first detection arrangement associated with the first local probe adapted to independently detect first measurement data refering to local measurements effected by said first local probe and

a second detection arrangement associated with the second local probe adapted to independently detect second measurement data refering to local measurements effected by said second local probe,

wherein at least one of said local probes has associated an interaction medium supply or an interaction medium receptacle for bringing or holding interaction medium in a region around at least an interaction portion of the respective local probe and at least a portion of said sample or said reference surface near said interaction portion or the respective local probe, said interaction medium bringing about or influencing a local interaction of the respective local probe with the sample or the reference surface.

6. A local probe measuring device for measuring local interactions between a local probe arrangement and a sample, comprising:

a first local probe adapted to interact locally with a sample or a reference surface,

a second local probe adapted to interact locally with the sample or a reference surface,

a rigid mechanical coupling between the first local probe and the second local probe,

a positioning arrangement adapted to commonly adjust

at least one of a first distance of the first local probe with respect to the sample or the reference surface and a first local interaction of the first probe with the sample or the reference surface and

at least one of a second distance of the second local probe with respect to the sample or the reference surface and a second local interaction of the second local probe with the sample or the reference surface,

a detection arrangement comprising a first detection arrangement associated with the first local probe adapted to detect at least one of the first distance and the first local interaction independently of the second distance and the second local interaction and

a second detection arrangement associated with the second local probe adapted to detect at least one of the second distance and the second local interaction independently of the first distance and the first interaction

wherein at least one of said local probes has associated an interaction field generator generating an interaction field to bring about or to influence said local interaction of the respective local probe with the sample or the reference surface.

7. The device according to claim 6, characterized in that said interaction field is an electromagnetic or optical field interacting with the sample or the reference surface.

8. The device according to claim 7, characterized by said local interaction of the respective local probe with said sample or said reference surface being a detection of a response of the sample or the reference surface to the interaction field.

9. The device according to claim 8, characterized by said detection of said response comprising a detection of an optical near-field resulting from an illumination of said sample or reference surface by an optical field serving as interaction field, the respective local probe having associated an aperture to serve as near-field optical microscopy probe.

10. A local probe measuring device for measuring local interactions between a local probe arrangement and a sample, comprising:

a first local probe adapted to interact locally with a sample or a reference surface,

a second local probe adapted to interact locally with the sample or a reference surface,

a rigid mechanical coupling between the first local probe and the second local probe,

a positioning arrangement adapted to commonly adjust

at least one of a first distance of the first local probe with respect to the sample or the reference surface and a first local interaction of the first probe with the sample or the reference surface and

at least one of a second distance of the second local probe with respect to the sample or the reference surface and a second local interaction of the second local probe with the sample or the reference surface,

a detection arrangement comprising a first detection arrangement associated with the first local probe adapted to detect at least one of the first distance and the first local interaction independently of the second distance and the second local interaction and

a second detection arrangement associated with the second local probe adapted to detect at least one of the second distance and the second local interaction independently of the first distance and the first interaction

wherein at least one of said local probes has associated an interaction medium supply or an interaction medium receptacle for bringing or holding interaction medium in a region around at least an interaction portion of the respective local probe and at least a portion of said sample or said reference surface near said interaction portion or the respective local probe, said interaction medium bringing about or influencing said local interaction of the respective local probe with the sample or the reference surface.

11. A local probe measuring device for measuring local interactions between a cantilever probe arrangement and a sample, comprising:

a first cantilever probe adapted to interact locally with a sample or a reference surface,

a second cantilever probe adapted to interact locally with the sample or a reference surface,

a rigid mechanical coupling between a base section of the first cantilever probe and a base section of the second cantilever probe,

a positioning arrangement adapted to commonly adjust

a first distance of the base section of the first cantilever 25 probe with respect to the sample or the reference surface and

a second distance of the base section of the second local probe with respect to the sample or the reference surface,

a detection arrangement comprising

a first detection arrangement associated with the first cantilever probe adapted to independently detect at least one of a first deflection of the first cantilever probe and a first local interaction of the first cantilever probe with said sample or reference surface and

a second detection arrangement associated with the second cantilever probe adapted to independently detect at least one of a second deflection of the second cantilever probe and a second local interaction of the second cantilever probe with said sample or reference surface.

wherein at least one of said cantilever probes has associated an interaction field generator generating an interaction field to bring about or to influence said local interaction of the respective cantilever probe with the sample or the reference surface.

12. The device according to claim 11, characterized in that said interaction field is an electromagnetic or optical field interacting with the sample or the reference surface.

13. The device according to claim 12, characterized by said local interaction of the respective cantilever probe with said sample or said reference surface being a detection of a response of the sample or the reference surface to the interaction field.

14. The device according to claim 13, characterized by said detection of said response comprising a detection of an optical near-field resulting from an illumination of said sample or reference surface by an optical field serving as interaction field, the respective cantilever probe having associated an aperture to serve as near-field optical microscopy probe.

15. A local probe measuring device for measuring local interactions between a cantilever probe arrangement and a sample, comprising:

a first cantilever probe adapted to interact locally with a sample or a reference surface,

a second cantilever probe adapted to interact locally with the sample or a reference surface,

a rigid mechanical coupling between a base section of the first cantilever probe and a base section of the second cantilever probe,

a positioning arrangement adapted to commonly adjust

a first distance of the base section of the first cantilever 25 probe with respect to the sample or the reference surface and

a second distance of the base section of the second local probe with respect to the sample or the reference surface,

a detection arrangement comprising

a first detection arrangement associated with the first cantilever probe adapted to independently detect at least one of a first deflection of the first cantilever probe and a first local interaction of the first cantilever probe with said sample or reference surface and

a second detection arrangement associated with the second cantilever probe adapted to independently detect at least one of a second deflection of the second cantilever probe and a second local interaction of the second cantilever probe with said sample or reference surface.

wherein at least one of said cantilever probes has associated an interaction medium supply or an interaction medium receptacle for bringing or holding interaction medium in a region around at least an interaction portion of the respective cantilever probe and at least a portion of said sample or said reference surface near said interaction portion or the respective cantilever probe, said interaction medium bringing about or influencing said local interaction of the respective cantilever probe with the sample or the reference surface.

16. A method of effecting local measurements referring to a sample, comprising:

providing at least two local probes in a positional relation with respect to a sample or a reference surface,

adjusting a respective measurement condition for at least one of said local probes on the basis of measurement effected with respect to at least one other of said probes, respective local probe with respect to said sample or said reference surface,

wherein that at least one of an interaction field and an interaction medium is provided in interaction relation with at least one of said local probes and with said sample or said reference surface.

17. The method according to claim 16, characterized in that said interaction field is one of an electromagnetic field, an optical field, a static magnetic field and a static electric field.

18. The method according to claim 16, characterized in that said interaction medium is one of a liquid and a gas or one of a mixture of liquids and a mixture of gases.

19. A method of effecting local manipulations refering to a sample, comprising:

providing at least two local probes in a positional relation with respect to a sample or a reference surface,

adjusting a respective manipulation condition for at least one of said local probes on the basis of measurements effected with respect to at least one other of said local probes,

manipulating said sample by means of said at least one local probe with reference to said measurements effected with respect to said at least one other local probe,

wherein at least one of an interaction field and an interaction medium is provided in interaction relation with at least one of said local probes and with said sample or said reference surface.

20. The method according to claim 19, characterized in that said interaction field is one of an electromagnetic field, an optical field, a static magnetic field and a static electric field.

21. The method according to claim 19, characterized in that said interaction medium is one of a liquid and a gas or one of a mixture of liquids and a mixture of gases.