Composite graft
First Claim
1. A composite multi-layered vascular graft prosthesis, comprising:
- (A) a lumen-forming blood contacting inner layer consisting essentially of substantially acellular elastin; and
(B) an outer layer comprising a sufficient amount of a collagen matrix adhered to the inner layer to provide mechanical strength to the inner layer of elastin when the prosthesis is implanted in the body.
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Accused Products
Abstract
Composite vascular grafts, their methods of construction, and methods of use are disclosed. In some embodiments, the grafts are tubular multilayer composite grafts having a luminal blood-contacting elastin layer and an outer collagen layer to impart mechanical strength to the elastin layer. The elastin and collagen layers may comprise substantially acelluar matrixes isolated from the tissue of an animal. In particular embodiments the blood contacting layer consists essentially of pure elastin, and is substantially free of collagen. An adhesive may be used to secure the collagen and elastin layers to one another. Growth factors may be added to the adhesive of the elastin or collagen layers to promote in growth of cells into the graft.
64 Citations
20 Claims
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1. A composite multi-layered vascular graft prosthesis, comprising:
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(A) a lumen-forming blood contacting inner layer consisting essentially of substantially acellular elastin; and
(B) an outer layer comprising a sufficient amount of a collagen matrix adhered to the inner layer to provide mechanical strength to the inner layer of elastin when the prosthesis is implanted in the body. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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- 16. A method of constructing a graft prosthesis comprising wrapping a collagen matrix around an elastin matrix to form a tubular graft prosthesis having a luminal blood-contacting layer consisting essentially of elastin, and an outer collagen layer that imparts mechanical strength to the graft prosthesis.
Specification