A COMBINATION OF MITOCHONDRIAL NUTRIENTS FOR RELIEVING STRESS, PREVENTING AND IMPROVING STRESS-RELATED DISORDERS

• US 20060257502A1
• Filed: 05/11/2005
• Published: 11/16/2006
• Est. Priority Date: 05/11/2005
• Status: Abandoned Application

• Current Assignee: Jiankang Liu
• Original Assignee: Jiankang Liu
• Inventors: Liu, Jiankang
• Application Number:
  US10/908,425
• Publication Number:
  US 20060257502A1
• Time in Patent Office: Days
• US Class Current: 424/682
• CPC Class Codes: A23L 33/15 Vitamins
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/302 having a modulating effect on age
• CPC Class Codes: A23V 2250/026 Alpha lipoic acid, thioctic acid
• CPC Class Codes: A23V 2250/0652 Tyrosine
• CPC Class Codes: A23V 2250/1578 Calcium
• CPC Class Codes: A23V 2250/1852 Phosphatidyl Serine
• CPC Class Codes: A23V 2250/7042 Vitamin B1
• CPC Class Codes: A23V 2250/7046 Vitamin B3 niacin
• CPC Class Codes: A23V 2250/705 Vitamin B5 pantothenic acid
• CPC Class Codes: A23V 2250/7056 Vitamin B8 Folic acid
• CPC Class Codes: A23V 2250/706 Vitamin B12
• CPC Class Codes: A23V 2250/708 Vitamin C
• CPC Class Codes: A23V 2250/712 Vitamin E
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 2800/92 Oral administration
• CPC Class Codes: A61K 31/198 Alpha-amino acids, e.g. alanine or edetic acid [EDTA] betaine A61K31/205; proline A61K31/401; tryptophan A61K31/405; histidine A61K31/4172; peptides not degraded to individual amino acids A61K38/00
• CPC Class Codes: A61K 31/355 Tocopherols, e.g. vitamin E
• CPC Class Codes: A61K 31/385 having two or more sulfur atoms in the same ring
• CPC Class Codes: A61K 31/4415 Pyridoxine, i.e. Vitamin B6 pyridoxal phosphate A61K31/675
• CPC Class Codes: A61K 31/51 : Thiamines, e.g. vitamin B1
• CPC Class Codes: A61K 31/525 : Isoalloxazines, e.g. riboflavins, vitamin B2
• CPC Class Codes: A61K 31/573 : substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
• CPC Class Codes: A61K 31/685 : one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
• CPC Class Codes: A61K 31/714 : Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 33/06 : Aluminium, calcium or magnesium; Compounds thereof , e.g. clay
• CPC Class Codes: A61K 8/673 : Vitamin B group
• CPC Class Codes: A61Q 19/08 : Anti-ageing preparations

Abstract

A dietary supplement of mitochondrial nutrients is designed for relieving stress, preventing and improving stress-related disorders, such as chronic fatigue syndrome, diabetes, age-associated cognitive dysfunction and diseases (Parkinson'"'"'s and Alzheimer'"'"'s disease). The supplement composition has the following nutrients: B vitamins (cyanocobalamin 2-1,000 ug, thiamin 1-1,000 mg, niacin 15-2,000 mg, pyridoxine 1-1,000 mg, Pantothenate 5-150 mg, folic acid 400-40,000 ug), alpha-tocopherol 10-800 mg, ascorbic acid 50-10,000 mg, calcium 20-2,000 mg, vitamin A 200-10,000 ug, alpha-lipoic acid 100-1,000 mg, N-acetyl cysteine 100-3,000 mg, L-carnosine 100-9,000 mg, tyrosine 100-9,000 mg, vanillin 10-100 mg, phosphatidylserine 10-800 mg, resveratrol 10-50 mg, dehydroepiandrosterone 1-50 mg, and melatonin 0.1-3 mg, all of which have been individually used experimentally or clinically for relieving stress, preventing and treating age- and stress-related disorders and diseases but no combination of these compounds has been used. Many embodiments also contain at least one adjunct ingredient such as coenzyme Q 10-200 mg, acetyl-L-carnitine 100-2,000 mg, choline 50-1,000 mg, and creatine 100-2,000 mg.

Claims

1. A method for relieving stress, preventing and improving stress-related disorders comprising orally use of a composition containing mitochondrial nutrients.

2. A method according to claim 1 wherein the stress includes all stress-related abnormalities in physiology, psychology, and behavior for every age group experienced in working, studying, and daily life. Psychological abnormalities include anxiety, loneliness, boredom, helplessness, aggressiveness, restlessness, over-reaction, loss of motivation;

Physiological abnormalities includes tenseness, stiff neck, tired muscle, flushing of skin, chronic indigestion, dizziness, stomachaches, cold sweats;

Behavioral abnormalities include impatience, carelessness, sighing, unable to laugh, eating disorder, forgetfulness, sleeplessness, and reduced social communication. Stress-related disorders include aging acceleration, ulcer, cancer, type II diabetes, obesity, hypertension, osteoporosis, depression, glaucoma, cataracts, Alzheimer'"'"'s disease, Parkinson'"'"'s disease, and cardiovascular disease.

3. A method according to claim 1 wherein the mitochondrial nutrients are cyanocobalamin, thiamin, niacin, pyridoxine, pantothenate, folic acid, alpha-tocopherol, ascorbic acid, calcium, vitamin A, alpha-lipoic acid, N-acetyl cysteine, L-carnosine, tyrosine, vanillin, phosphatidylserine, resveratrol, dehydroepiandrosterone, and melatonin.

4. A method according to claim 1 wherein the composition comprises cyanocobalamin 2-1,000 ug, thiamin 1-1,000 mg, niacin 15-2,000 mg, pyridoxine 1-1,000 mg, pantothenate 5-150 mg, folic acid 400-40,000 ug, alpha-tocopherol 10-800 mg, ascorbic acid 50-10,000 mg, calcium 20-2,000mg, vitamin A 200-10,000 ug, alpha-lipoic acid 100-1,000 mg, N-acetyl cysteine 100-3,000 mg, L-carnosine 100-9,000 mg, tyrosine 100-9,000 mg, vanillin 10-100 mg, phosphatidylserine 10-800 mg, resveratrol 10-50 mg, dehydroepiandrosterone 1-50 mg, and melatonin 0.1-3 mg. The amounts of each ingredients for each specified method is composed according to the specific aim according the chemical properties, biological function, adding or synergistic actions of the ingredients used. Since the important concept is to have a mixture not only with different functions, but also with adding and the synergistic effects for optimum effects, the amounts used will be much smaller than that used singly.

5. A method according to claim 1 where the composition further contains an active ingredient selected from the group of mitochondrial nutrients consisting of coenzyme Q, acetyl-L-carnitine, choline, and creatine.

6. A method according to claim 4 wherein the composition comprises coenzyme Q 10-200 mg, acetyl-L-carnitine 100-2,000 mg, choline 50-1,000 mg, and creatine 100-2,000 mg.

Page 48 of 49