Detection and measurement of hematological parameters characterizing cellular blood components
First Claim
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1. A method for detecting volatile markers associated with hematological conditions or diseases, said method comprising the steps of:
- (a) collecting a sample of blood from a patient into a container, wherein said container includes a cover and provides room for a headspace sample;
(b) analyzing the headspace sample with sensor technology to determine the presence of the volatile markers associated with hematological conditions or diseases.
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Abstract
Systems and methods for the diagnostic analysis of blood samples. The present invention uses sensor technology useful in the analysis of headspace sample from blood to provide an efficient and accurate means for identifying the presence of a volatile marker associated with hematological diseases or conditions. In a preferred embodiment, the sensor technology of the present invention includes detecting means such as RNA oligonucleotide chains or aptamers.
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Citations
23 Claims
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1. A method for detecting volatile markers associated with hematological conditions or diseases, said method comprising the steps of:
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(a) collecting a sample of blood from a patient into a container, wherein said container includes a cover and provides room for a headspace sample;
(b) analyzing the headspace sample with sensor technology to determine the presence of the volatile markers associated with hematological conditions or diseases. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for non-invasive, real-time assessment of anticoagulation levels in a patient, said method comprising the steps of:
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a) administering to a patient an anticoagulant;
b) administering a composition comprising nanoparticles, wherein each nanoparticle comprises a detector and a volatile marker, wherein detection of a target biomarker associated with anticoagulation levels causes the release of the volatile marker for detection by the sensor technology;
c) collecting a bodily fluid sample from the patient;
d) applying sensor technology to the bodily fluid sample to determine the presence of volatile markers associated with anticoagulation levels; and
e) determining anticoagulation levels in the patient based on the concentration of volatile markers in the bodily fluid sample. - View Dependent Claims (19, 20, 21, 22, 23)
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Specification