Methods and sequences to suppress primate huntington gene expression
First Claim
Patent Images
1. A nucleic acid molecule comprising a first strand and a second strand wherein said first strand comprises a nucleotide sequence and wherein said second strand comprises the reverse complement of said first strand and wherein said nucleic acid molecule suppresses the expression of both Macaca mulatta and Homo sapiens mRNA sequences that encode for huntingtin.
1 Assignment
0 Petitions
Accused Products
Abstract
Disclosed herein are sequences, molecules and methods used to suppress the expression of HD genes encoding for huntingtin protein in primates including Macaca mulatta and Homo sapiens. These sequences, molecules and methods aid in the study of the pathogenesis of HD and can also provide a treatment for this disease.
93 Citations
36 Claims
-
1. A nucleic acid molecule comprising a first strand and a second strand wherein said first strand comprises a nucleotide sequence and wherein said second strand comprises the reverse complement of said first strand and wherein said nucleic acid molecule suppresses the expression of both Macaca mulatta and Homo sapiens mRNA sequences that encode for huntingtin.
-
2. An isolated nucleic acid duplex comprising a first strand of nucleic acid and a second strand of nucleic acid, wherein the first strand comprises at least 19 contiguous nucleotides encoded by the group consisting of SEQ ID NO:
- 1, SEQ ID NO;
2, SEQ ID NO;
3, SEQ ID NO;
4, SEQ ID NO;
5, SEQ ID NO;
6, SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, and SEQ ID NO;
15 and wherein the second strand is complementary to at least 15 contiguous nucleotides of the first strand. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
- 1, SEQ ID NO;
-
3. An isolated nucleic acid duplex comprising a first strand of nucleic acid and a second strand of nucleic acid, wherein the first strand comprises at least 27 contiguous nucleotides encoded by the group consisting of SEQ ID NO:
- 9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, and SEQ ID NO;
15 and wherein the second strand is complementary to at least 23 contiguous nucleotides of the first strand. - View Dependent Claims (20)
- 9, SEQ ID NO;
Specification