Integration of fluids and reagents into self-contained cartridges containing sensor elements and reagent delivery systems
First Claim
1. A system for detecting an analyte in a sample comprising:
- a cartridge, wherein a detection system is disposed in or on the cartridge, wherein the detection system is configured to produce a signal in the presence of the analyte during use, and wherein the cartridge comprises an integrated waste reservoir that collects reagent and/or sample during use;
a reagent delivery system disposed in or on the cartridge, the reagent delivery system comprising one or more reagents, and wherein the reagent delivery system is configured to deliver one or more reagents to the sample during use; and
an optical platform, wherein the optical platform is configured to detect the signal produced by the interaction of the sample and/or analyte with the detection system during use.
1 Assignment
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Accused Products
Abstract
Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator'"'"'s contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
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Citations
71 Claims
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1. A system for detecting an analyte in a sample comprising:
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a cartridge, wherein a detection system is disposed in or on the cartridge, wherein the detection system is configured to produce a signal in the presence of the analyte during use, and wherein the cartridge comprises an integrated waste reservoir that collects reagent and/or sample during use;
a reagent delivery system disposed in or on the cartridge, the reagent delivery system comprising one or more reagents, and wherein the reagent delivery system is configured to deliver one or more reagents to the sample during use; and
an optical platform, wherein the optical platform is configured to detect the signal produced by the interaction of the sample and/or analyte with the detection system during use. - View Dependent Claims (2, 3, 4, 5, 6, 8, 9, 10, 12, 14, 16, 21, 22, 33, 36, 37, 43, 51, 55, 58, 61, 63, 64, 66, 70, 71)
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Specification