Process of preparing ziprasidone mesylate
First Claim
Patent Images
1. A process for preparing amorphous ziprasidone mesylate comprising the step of spray-drying a solution of ziprasidone mesylate at an outlet temperature of above 90°
- C. in a solvent selected from a group consisting of;
C1-C5 alcohols, C2-C8 ethers, glacial acetic acid, optionally in mixture with water.
3 Assignments
0 Petitions
Accused Products
Abstract
The invention provides a process of preparing ziprasidone mesylate.
-
Citations
27 Claims
-
1. A process for preparing amorphous ziprasidone mesylate comprising the step of spray-drying a solution of ziprasidone mesylate at an outlet temperature of above 90°
- C. in a solvent selected from a group consisting of;
C1-C5 alcohols, C2-C8 ethers, glacial acetic acid, optionally in mixture with water. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
- C. in a solvent selected from a group consisting of;
-
13. A process for preparing ziprasidone mesylate crystal form characterized by X-ray powder diffraction peaks at 11.7, 17.3, 23.5, 24.2, and 25.2 degrees two-theta, ±
- 0.2 degrees two-theta (herein defined as Form I) comprising the step of spray-drying a solution of ziprasidone mesylate an outlet temperature of above 70°
C. in a solvent selected from a group consisting of;
glacial acetic acid, optionally in mixture with C2-C8 ethers, and collecting the obtained Form I. - View Dependent Claims (14, 15, 16, 17, 18, 19)
- 0.2 degrees two-theta (herein defined as Form I) comprising the step of spray-drying a solution of ziprasidone mesylate an outlet temperature of above 70°
-
20. A process for preparing ziprasidone mesylate crystal form characterized by X-ray powder diffraction peaks at 17.1, 18.7, 23.8, and 24.4 degrees two-theta, +0.2 degrees two-theta (herein defined as Form VIII) comprising the step of spray-drying a solution of ziprasidone mesylate at an outlet temperature of from about above 45°
- C. to about 70°
C. in a solvent selected from the group consisting of;
C1-C5 alcohols, optionally in mixture with water. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27)
- C. to about 70°
Specification