Benzimidazolidinone derivatives as muscarinic agents
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Abstract
Benzimidazolidinone derivative compounds, which increase acetylcholine signaling or effect in the brain, and highly selective muscarinic agonists, particularly for the M1 and/or M4 receptor subtypes, pharmaceutical compositions comprising the same, as well as methods of treating psychosis using these compounds are disclosed.
26 Citations
24 Claims
- 1. A compound of Formula I
- 14. A method of treating or preventing mental disease or disorder in a mammal comprising identifying a mammal in need thereof and administering to said mammal at least one compound of Formula I
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17. A method of treating or preventing a disease or disorder associated with increased intraocular pressure in a mammal comprising identifying a mammal in need thereof and administering to said mammal at least one compound of Formula I
- 18. A method of increasing an activity of a cholinergic receptor comprising contacting the cholinergic receptor or a system containing the cholinergic receptor with an effective amount of at least one compound of Formula I
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23. A method of prophylactic or curative treatment of psychosis or alleviation of symptoms of psychosis in a mammal, comprising administering to said mammal an effective amount of a compound of Formula I
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24. A method of modulating or preventing the progression or formation of amyloid plaques in an individual susceptible to or affected by Alzheimer'"'"'s Disease, comprising administering an effective amount sufficient to modulate amyloid precursor protein processing of a compound of Formula I
Specification