Silicone based membranes for use in implantable glucose sensors
First Claim
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1. A membrane layer for use in an analyte sensor, comprising a blend of a silicone polymer with a co-polymer comprising a polymeric hydrophobic domain and a polymeric hydrophilic domain, wherein the membrane is adapted to permit diffusion of both the analyte and oxygen therethrough.
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Abstract
Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.
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Citations
44 Claims
- 1. A membrane layer for use in an analyte sensor, comprising a blend of a silicone polymer with a co-polymer comprising a polymeric hydrophobic domain and a polymeric hydrophilic domain, wherein the membrane is adapted to permit diffusion of both the analyte and oxygen therethrough.
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9. An implantable analyte sensor, comprising:
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an electrode adapted to directly or indirectly detect the analyte; and
at least one membrane layer positioned over the electrode comprising a blend of a silicone polymer with a co-polymer comprising a polymeric hydrophobic domain and a polymeric hydrophilic domain. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. An implantable analyte sensor, comprising:
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an enzyme layer comprising an enzyme for which the analyte is a substrate; and
a bioprotective layer positioned between the enzyme layer and tissue adjacent to the sensor when implanted, wherein the bioprotective layer comprises a blend of a silicone polymer with a co-polymer comprising a polymeric hydrophobic domain and a polymeric hydrophilic domain. - View Dependent Claims (31, 32, 33, 34, 35)
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36. An implantable analyte sensor, comprising:
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an enzyme layer comprising an enzyme for which the analyte is a substrate; and
a diffusion resistance layer positioned between the enzyme layer and tissue adjacent to the sensor when implanted, wherein the diffusion resistance layer comprises a blend of a silicone polymer with a co-polymer comprising a polymeric hydrophobic domain and a polymeric hydrophilic domain. - View Dependent Claims (37, 38, 39, 40, 41, 42, 43, 44)
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Specification