Enhancements to the detection of pulmonary edema when using transthoracic impedance
First Claim
1. A system comprising:
- an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from a subject;
a parameter collection device, adapted to sense or receive physiologic information about the subject, the physiologic information selected from a physiologic information group consisting essentially of;
at least one heart sound, at least one lung sound, a respiratory pattern, a weight, a neurohormone level, a creatinine level, and a heart wall motion; and
a processor, coupled with the thoracic impedance measurement circuit to accept the thoracic impedance signal, and coupled with the parameter collection device to accept the physiologic information, wherein the processor is adapted to determine a pulmonary edema indication using the thoracic impedance signal and the physiologic information.
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Abstract
This patent document discusses, among other things, systems, devices, and methods for enhancing detection of pulmonary edema using, in addition to thoracic impedance, one or a combination of: physiologic information about a subject, at least one statistical parameter, a user-programmable detection level, at least one parameter associated with a previous pulmonary edema event, and patient symptom information about the subject. In one example, a (base) thoracic impedance threshold is modified to an adjusted thoracic impedance threshold. The adjusted thoracic impedance threshold provides an increased sensitivity of pulmonary edema detection as compared to the base thoracic impedance threshold. In another example, an alert is provided to a subject, a caregiver, or other user based on a pulmonary edema indication determined by the present systems, devices, and methods. In a further example, a therapy (provided to the subject) is adjusted or initiated in response to the pulmonary edema indication.
229 Citations
26 Claims
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1. A system comprising:
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an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from a subject;
a parameter collection device, adapted to sense or receive physiologic information about the subject, the physiologic information selected from a physiologic information group consisting essentially of;
at least one heart sound, at least one lung sound, a respiratory pattern, a weight, a neurohormone level, a creatinine level, and a heart wall motion; and
a processor, coupled with the thoracic impedance measurement circuit to accept the thoracic impedance signal, and coupled with the parameter collection device to accept the physiologic information, wherein the processor is adapted to determine a pulmonary edema indication using the thoracic impedance signal and the physiologic information. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method comprising:
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implantably sensing a thoracic impedance signal from the thorax of a subject;
sensing or receiving physiologic information about the subject, the physiologic information selected from a physiologic information group consisting essentially of;
at least one heart sound, at least one lung sound, a respiratory pattern, a weight, a neurohormone level, a creatinine level, and a heart wall motion; and
determining a pulmonary edema indication using the thoracic impedance signal and the physiologic information, wherein determining the pulmonary edema indication includes comparing the thoracic impedance signal to a thoracic impedance threshold. - View Dependent Claims (10, 11, 12, 13)
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14. A system comprising:
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an implantable thoracic impedance measurement circuit, adapted to sense a thoracic impedance signal from a subject;
a parameter collection device, adapted to sense or receive patient symptom information about the subject, the patient symptom information selected from a patient symptom group consisting essentially of;
a shortness of breath, a difficulty breathing, at least one wheeze, at least one cough, a feeling of anxiety, a feeling of restlessness, an excessive level of perspiration, an indication of pallor, a nasal flare, a decreased level of awareness, and an increased heart rate;
a processor, coupled with the thoracic impedance measurement circuit to accept the thoracic impedance signal, and coupled with the parameter collection device to accept the patient symptom information, wherein the processor is adapted to determine a pulmonary edema indication using the thoracic impedance signal and the patient symptom information. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21)
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22. A method comprising:
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implantably sensing a thoracic impedance signal from the thorax of a subject;
sensing or receiving at least one patient symptom about the subject, the patient symptom selected from a group consisting essentially of;
a shortness of breath, a difficulty breathing, at least one wheeze, at least one cough, a feeling of anxiety, a feeling of restlessness, an excessive level of perspiration, an indication of pallor, a nasal flare, a decreased level of awareness, and an increased heart rate; and
determining a pulmonary edema indication using the at least one patient symptom, wherein determining the pulmonary edema indication includes comparing the thoracic impedance signal to a thoracic impedance threshold. - View Dependent Claims (23, 24, 25, 26)
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Specification