Glucose sensor and glucose level measuring apparatus
First Claim
1. A glucose sensor comprising an electrode including a conductive component and glucose dehydrogenase immobilized to the conductive component;
- wherein the glucose dehydrogenase is a protein complex including a catalytic activity subunit in which flavin adenine dinucleotide is bound as coenzyme and which has glucose dehydrogenase activity, and an electron mediator subunit for supplying an electron donated from the catalytic activity subunit to the conductive component.
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Abstract
The present invention relates to a glucose sensor (2) including an electrode (32) which includes a conductive component and glucose dehydrogenase immobilized to the conductive component. As the glucose dehydrogenase, use is made of a protein complex including a catalytic activity subunit which has glucose dehydrogenase activity, and an electron mediator subunit for supplying an electron donated from the catalytic activity subunit to the conductive component. Preferably, the glucose sensor (2) is designed to continuously measure the glucose level or successively measure the glucose level a plurality of times.
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Citations
20 Claims
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1. A glucose sensor comprising an electrode including a conductive component and glucose dehydrogenase immobilized to the conductive component;
wherein the glucose dehydrogenase is a protein complex including a catalytic activity subunit in which flavin adenine dinucleotide is bound as coenzyme and which has glucose dehydrogenase activity, and an electron mediator subunit for supplying an electron donated from the catalytic activity subunit to the conductive component. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A glucose level measuring apparatus designed to continuously measure a glucose level or successively measure a glucose level a plurality of times based on blood or interstitial fluid sampled from subcutaneous tissue, the apparatus comprising:
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a glucose sensor including an electrode which includes a conductive component and glucose dehydrogenase immobilized to the conductive component;
a measurer for measuring response quantity related to amount of electron transfer between the blood or interstitial fluid and the electrode;
a computation unit for computing a glucose level based on the measurement by the measurer; and
a controller for controlling timing at which the glucose level is computed at the computation unit;
wherein the glucose dehydrogenase is a protein complex including a catalytic activity subunit in which flavin adenine dinucleotide is bound as coenzyme and which has glucose dehydrogenase activity, and an electron mediator subunit for supplying an electron donated from the catalytic activity subunit to the conductive component. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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Specification