Implantable delivery device for administering pharmacological agents to an internal portion of a body
First Claim
1. An implantable refillable device to deliver pharmacologic agents through a sclera to an internal portion of an eye comprising a hollow reservoir;
- a delivery tube having a first end and a second end, said first end communicating with the hollow reservoir and said second end terminating in a dispensing outlet and wherein said delivery tube is configured in a selected shape to extend from the hollow reservoir anterior in an eye to a posterior segment in an eye adjoining a sclera;
said second end being configured to position said dispensing outlet in contact with or contiguous a sclera and being located posteriorly in an eye and proximate to an internal portion of an eye to be treated with a pharmacologic agent.
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Accused Products
Abstract
An implantable refillable device to deliver pharmacologic agents through a sclera to an internal portion of an eye is shown. The device comprises a hollow reservoir and a delivery tube. The delivery tube has a proximal end and a distal end. The proximal end communicates with the hollow reservoir and the distal end terminates in a dispensing outlet. The delivery tube is configured in a selected shape to extend from the hollow reservoir anterior in an eye to a posterior segment posterior in an eye adjoining a sclera. The second end is configured to position the dispensing outlet in contact with or contiguous the sclera and is located posteriorly in an eye and proximate to an internal portion of an eye to be treated with a pharmacologic agent. An implantable device to deliver pharmacologic agents through an outer surface tissue of an organ is also shown.
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Citations
48 Claims
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1. An implantable refillable device to deliver pharmacologic agents through a sclera to an internal portion of an eye comprising
a hollow reservoir; -
a delivery tube having a first end and a second end, said first end communicating with the hollow reservoir and said second end terminating in a dispensing outlet and wherein said delivery tube is configured in a selected shape to extend from the hollow reservoir anterior in an eye to a posterior segment in an eye adjoining a sclera;
said second end being configured to position said dispensing outlet in contact with or contiguous a sclera and being located posteriorly in an eye and proximate to an internal portion of an eye to be treated with a pharmacologic agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. An implantable refillable device to deliver drugs through a posterior outer surface of an eye to an internal portion of an eye comprising
a hollow reservoir, said hollow reservoir having an internal cavity and a needle insertion section, said needle insertion section being configured to retain a drug located within the internal cavity from refluxing over the eye and being positioned relative to the anterior portion of an eye to enable a syringe needle to be passed through said needle insertion section and into the internal cavity to enable filling of the internal cavity with a drug and withdrawing of a drug from the internal cavity; - and
a delivery tube having a proximal end and a distal end, said proximal end communicating with the hollow reservoir and said distal end terminating in a drug dispensing outlet wherein said delivery tube is configured in a generally curved shape to extend from the hollow reservoir anterior in an eye to a posterior segment posterior in an eye adjoining a sclera;
said second end being configured to position said drug dispensing outlet in contact with or contiguous a posterior outer surface of an eye. - View Dependent Claims (21, 22, 23, 25)
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26. An implantable refillable device to deliver a pharmacologic agent directly through an outer surface of an eye to an internal portion of an eye to be treated comprising
a hollow reservoir; -
a delivery tube having a first end and a second end, said first end communicating with the hollow reservoir and said second end terminating in a pharmacologic agent dispensing outlet wherein said delivery tube is configured in a shape to extend from the hollow reservoir anterior in an eye to a posterior segment posterior in an eye and adjoining a sclera;
said second end being configured to be position said a pharmacologic agent-dispensing outlet in contact with or contiguous a sclera of an eye locate above an internal portion of an eye to be treated with a pharmacologic agent. - View Dependent Claims (27, 28, 29)
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30. A method for treating an eye comprising the steps of
forming an implantable refillable device to deliver a pharmacologic agent to an internal portion of an eye having a hollow reservoir and a delivery tube having a first end and a second end wherein said first end communicates with the hollow reservoir, wherein said delivery tube is configured in a shape to extend from the hollow reservoir anterior in an eye to a posterior segment posterior in an eye adjoining a sclera and wherein said second end terminates in a dispensing outlet to be position in contact with or contiguous a sclera of an eye; - and
surgically implanting said device under the Tenon'"'"'s capsule and in contact with or contiguous the sclera of an eye with the hollow reservoir positioned anteriorly on the sclera at a location where a needle can be inserted into the hollow reservoir and with said dispensing outlet being is located posteriorly on the sclera and proximate the location of an internal portion of an eye to be treated by a pharmacological agent. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method for removing a pharmacologic agent from an implant having a needle insert section and a hollow reservoir comprising the steps of:
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inserting a needle through the needle insertion section;
injecting a small amount of sterile air through the needle into the hollow reservoir;
allowing bubbles of sterile air to rise to the superior part of the hollow reservoir;
withdrawing an appropriate quantity of pharmacologic agent from the hollow cavity using the needle; and
alternating injecting another small amount of sterile air through the needle into the hollow reservoir and withdrawing through the needle an appropriate quantity of pharmacologic agent until the pharmacologic agent is removed. - View Dependent Claims (41, 42)
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43. An implantable device to deliver pharmacologic agents through an outer surface tissue of an organ comprising a hollow reservoir;
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a delivery tube having a dispensing outlet and wherein said delivery tube is configured in a selected shape to extend from the hollow reservoir to a selected portion of the outer surface tissue of an organ;
said dispensing outlet being configured to be positioned in contact with or contiguous an outer tissue of an organ and proximate to an internal portion of a body to be treated with a pharmacologic agent.
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44. An implantable delivery device for delivering a therapeutic agent into a target tissue comprising
an enclosed therapeutic agent container having a dispensing outlet, said container being configured to be implanted in a tunnel or flap of the outer tissue of an organ wherein the dispensing outlet is engaged by and sealed within the tunnel by the outer tissue of an organ enabling administration of a therapeutic agent into the target tissue contiguous to the dispensing outlet.
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45. A method for treating an inner portion of an organ within a body having an outer tissue enclosing the organ comprising the steps of:
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forming a tunnel or flap in the outer tissue surrounding the organ; and
implanting within said tunnel or flap an implantable delivery device for delivering a therapeutic agent into a target tissue wherein said implantable delivery device includes a therapeutic agent container having a dispensing outlet and wherein said container is configured to be implanted into a tunnel or flap of the outer tissue of an organ and wherein the dispensing outlet is engaged by and sealed within the tunnel by the outer tissue of an organ enabling administration of a therapeutic agent into the target tissue contiguous to the dispensing outlet. - View Dependent Claims (46, 47, 48)
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Specification