Porous spun polymeric structures and method of making same
First Claim
1. A non-woven matrix material for use in a medical device comprising a non-woven three dimensional matrix of polymeric fibers wherein said matrix has a predetermined shape, a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size, and a plurality of connections between said fibers.
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Abstract
A non-woven polymeric matrix for separating leukocytes from a blood sample includes a non-woven three dimensional matrix formed from polymeric fibers having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size in the range of from about 10 μm to about 250 μm, and a plurality of connections between the plurality of fibers. The matrix is configured so as to remove at least about 98% of leukocytes from at least one unit of packed red blood cells. Methods of making and using the matrix are also provided.
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Citations
21 Claims
- 1. A non-woven matrix material for use in a medical device comprising a non-woven three dimensional matrix of polymeric fibers wherein said matrix has a predetermined shape, a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size, and a plurality of connections between said fibers.
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2. A non-woven matrix material for use in a medical device comprising a non-woven three dimensional matrix wherein said matrix is formed by a method of selectively generating a uniform or varied micro-architecture within the three dimensional non-woven matrix, comprising the steps of:
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admixing at least one fiber forming polymer with a compatible solvent to form a flowable polymer mixture;
applying at least one fiber formed from said polymer mixture to a moveable table capable of motion in a first plane (x), a second plane (y) perpendicular to said first plane, and a third plane (z) perpendicular to said first plane (x) and said second plane (y); and
controlling movement of at least said table so as to form a three dimensional non-woven matrix of fibers having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size, and a plurality of connections between said fibers.
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15. A non-woven polymeric matrix for separating leukocytes from a blood sample, said matrix having a first upstream side and a second downstream side, and comprising:
a non-woven three dimensional matrix formed from polymeric fibers having a diameter of from about 5 μ
m to about 15 μ
m, the matrix having a predetermined pore volume fraction including a defined channel configuration, a predetermined pore size in the range of from about 10 μ
m to about 250 μ
m, a plurality of connections between said plurality of fibers, and being configured so as to remove at least about 98% of leukocytes from at least one unit of packed red blood cells.- View Dependent Claims (16, 17, 18, 19, 20, 21)
Specification