Invisible antimicrobial glove and hand antiseptic

• US 20060263323A1
• Filed: 03/24/2004
• Published: 11/23/2006
• Est. Priority Date: 03/24/2003
• Status: Active Grant

• Current Assignee: Becton, Dickinson & Co
• Original Assignee: Becton, Dickinson & Co
• Inventors: Hoang, Minh Quang, Hunt, Donald Edward
• Granted Patent: US 7,488,757 B2
• Time in Patent Office: Days
• US Class Current: 424/70.170
• CPC Class Codes: A61K 2800/28 Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
• CPC Class Codes: A61K 2800/54 Polymers characterized by specific structures/properties
• CPC Class Codes: A61K 2800/5426 cationic
• CPC Class Codes: A61K 2800/5922 At least two compounds being classified in the same subclass of A61K8/18
• CPC Class Codes: A61K 8/34 Alcohols
• CPC Class Codes: A61K 8/342 Alcohols having more than seven atoms in an unbroken chain
• CPC Class Codes: A61K 8/37 Esters of carboxylic acids
• CPC Class Codes: A61K 8/416 Quaternary ammonium compounds A61K8/35 takes precedence
• CPC Class Codes: A61K 8/43 Guanidines
• CPC Class Codes: A61K 8/46 containing sulfur A61K8/44 takes precedence
• CPC Class Codes: A61K 8/731 Cellulose; Quaternized cellulose derivatives
• CPC Class Codes: A61K 8/8176 Homopolymers of N-vinyl-pyrrolidones. Compositions of derivatives of such polymers
• CPC Class Codes: A61K 8/86 Polyethers
• CPC Class Codes: A61K 8/922 of vegetable origin
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations
• CPC Class Codes: A61Q 19/10 Washing or bathing preparations
• CPC Class Codes: B08B 3/04 Cleaning involving contact with liquid

Abstract

An alcohol based hand surgical scrub, which includes cationic anti-microbial agent preservatives, cationic polymer film-forming agents and a skin emollient, and provides a long term residual, anti-microbial “invisible glove” on the skin. The composition provides an immediate reduction in bacterial microbes. The polymer system creates an invisible film on the skin following solvent evaporation. This invisible film provides a lasting anti-microbial barrier on the skin which acts to prevent microbial growth.

Claims

1. A surgical scrub composition comprising:

(a) an alcohol;

(b) a cationic anti-microbial agent;

(c) a skin emollient; and

(d) a film-forming cationic polymer system.

2. The surgical scrub composition of claim 1, further comprising a silicone.

3. The surgical scrub composition of claim 2, wherein the silicone includes one or more of the group of dimethicone copolyol, cyclomethicone and dimethicone.

4. The surgical scrub composition of claim 1, further comprising one or more of the group of methylparaben and propylparaben.

5. The surgical scrub composition of claim 1, wherein the anti-microbial agent is one or more of the group including chlorhexidine digluconate, chloroxylenol, para-chloro-meta-xylenol, chlorhexidine diacetate, benzethonium chloride, benzalkonium chloride, hexetidine, germaben II, kathon CG, triclosan, hexachlorophenes, octenidine, and quaternary compounds.

6. The anti-microbial composition of claim 1, wherein the polymer system includes one or more of the group including incroquat behenyl TMS, incroquat CR concentrate, cellulose, polyvinylpyrolidone and waxes.

7. (canceled)

8. A method of using a surgical scrub composition for hand antisepsis comprising:

(a) applying a cleansing liquid to the skin;

(b) scrubbing the skin with an anti-microbial scrub solution;

(c) rinsing the anti-microbial scrub solution from the skin; and

(d) applying an effective amount of a surgical scrub composition including;

i. an alcohol;

ii. a cationic anti-microbial agent;

iii. a skin emollient; and

iv. a film-forming cationic polymer system.

9. The method of claim 8, wherein the surgical scrub composition includes:

the alcohol in an amount from about 60 to about 95 weight percent of the total composition;

the cationic anti-microbial agent in an amount from about 0.1 to about 5 weight percent of the total composition;

the skin emollient in an amount from about 0.1 to about 5 weight percent of the total composition; and

the film-forming cationic polymer system in amount from about 0.1 to about 5 weight percent of the total composition.

10. The method of claim 9, wherein the surgical scrub composition includes a silicone in an amount from about 0.1 to about 5 weight percent of the total composition.

11. The method of claim 8, wherein the film-forming polymer system includes one or more of the group including incroquat behenyl TMS, incroquat CR concentrate, cellulose, polyvinylpyrolidone and waxes.

12. The method of claim 8, wherein effective amount is 20 cc.

13. (canceled)

14. (canceled)

15. A surgical scrub composition comprising, in weight percent of the total composition:

(a) about 1 percent of 1-docosanol;

(b) about 0.45 percent of chlorhexidine digluconate;

(c) about 71 percent of alcohol;

(d) about 1.4 percent of glycerin;

(e) about 0.4 percent of incroquat BTMS;

(f) about 0.4 percent of isopropyl palmitate;

(g) about 0.06 percent of the group consisting of methylparaben and propylparaben; and

(h) about 23 percent of purified water.

16. (canceled)

17. A surgical scrub composition comprising:

(a) one or more alcohols selected from the group of ethyl alcohol, isopropyl alcohol, ethanol and n-propanol;

(b) one or more cationic anti-microbial agents selected from the group of chlorhexidine digluconate, chloroxylenol, para-chloro-meta-xylenol, chlorhexidine diacetate, benzethonium chloride, benzalkonium chloride, hexetidine, germaben II, kathon CG, triclosan, hexachlorophenes, octenidine and quaternary compounds;

(c) a skin emollient; and

(d) a film-forming cationic polymer system including one or more selected from the group of incroquat behenyl TMS, incroquat CR concentrate, cellulose, polyvinylpyrolidone, waxes, behenyl trimonium methosulfate containing compounds and stearalkonium chloride containing compounds.

18. The surgical scrub composition of claim 17, further comprising a silicone.

19. The surgical scrub composition of claim 17, further comprising one or more of methylparaben or propylparaben.