Treatment of bone disorders
First Claim
1. A method for treating a bone disorder in a mammal comprising administering to the mammal an effective amount of a CD20 antibody.
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Accused Products
Abstract
Methods of treatment of various bone indications, such as osteoporosis, in a mammal are provided wherein an effective amount of an antagonist that binds to a B-cell surface marker, such as a CD20 antibody, is administered, optionally also with another medicament such as an agent that treats such disorders in an effective amount. Articles of manufacture are also provided. Further, a method of inhibiting osteolysis in a mammal is provided comprising introducing into said mammal an isolated odontoprogenitor or osteoprogenitor cell comprising a nucleic acid encoding an antibody that binds to a B-cell surface marker.
175 Citations
71 Claims
- 1. A method for treating a bone disorder in a mammal comprising administering to the mammal an effective amount of a CD20 antibody.
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47. A method for treating a bone disorder in a mammal comprising administering to the mammal an effective amount of an antibody that binds to a B-cell surface marker.
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48. A method for treating a bone disorder in a mammal comprising administering to the mammal an effective amount of an antagonist that binds to a B-cell surface marker.
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49. An article of manufacture comprising:
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i. a container comprising a CD20 antibody; and
ii. a package insert with instructions for treating a bone disorder in a mammal, wherein the instructions indicate that an effective amount of the CD20 antibody is administered to the mammal. - View Dependent Claims (50, 51, 52)
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- 53. A method of inhibiting osteolysis in a mammal, comprising introducing into said mammal an isolated odontoprogenitor or osteoprogenitor cell comprising a nucleic acid encoding an antibody that binds to a B-cell surface marker.
Specification