Targeted chimeric molecules for cancer therapy
First Claim
1. A method of conferring or restoring chemosensitivity to one or more chemotherapy-resistant cancer cells in an individual, comprising delivering to the individual a therapeutically effective amount of a chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
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Accused Products
Abstract
The present invention concerns chimeric cancer therapeutic molecules comprising a targeting moiety and an anti-cell proliferation moiety. The anti-cell proliferation moiety may comprise a cytotoxic agent or an apoptosis-inducing factor, in specific embodiments. In particular embodiments, the anti-cell proliferation mechanism of the chimeric molecules comprises apoptotic pathways. In additional embodiments, the chimeric molecules of the present invention provide sensitivity to chemotherapy in a cell that is resistant to the chemotherapy.
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Citations
49 Claims
- 1. A method of conferring or restoring chemosensitivity to one or more chemotherapy-resistant cancer cells in an individual, comprising delivering to the individual a therapeutically effective amount of a chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
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44. A method of sensitizing one or more cancer cells in an individual to a chemotherapy, comprising administering to the individual a therapeutically effective amount of a chimeric molecule, said chimeric molecule comprising a cell-targeting moiety and an anti-cell proliferation moiety.
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45. A method of inducing apoptosis in one or more TNF-resistant cancer cells in an individual, comprising administering to the individual a therapeutically effective amount of a chimeric molecule, said chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
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46. A method of inducing apoptosis in one or more HER-2/neu overexpressing cancer cells in an individual, comprising administering to the individual a therapeutically effective amount of a chimeric molecule, said chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
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47. A method of inducing apoptosis in one or more gp240 antigen-positive cells in an individual, comprising administering to the individual a therapeutically effective amount of a chimeric molecule, said chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
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48. A method of treating cancers in an individual that are Her-2/neu overexpressing and Nf-κ
- B overexpressing, comprising administering to the individual a therapeutically effective amount of a chimeric molecule, said chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
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49. A method of treating cancer in an individual, comprising administering to the individual a therapeutically effective amount of at least one chemotherapeutic agent, wherein said agent acts by interrupting NF-κ
- B signaling, and a chimeric molecule, said chimeric molecule comprising a cell-specific targeting moiety and an anti-cell proliferation moiety.
Specification